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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제24권 제4호
- 발행연도
- 2019.1
- 수록면
- 220 - 225 (6page)
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초록· 키워드
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Recent data suggest that subclinical atherosclerosis is more related to visceral adipose tissue distribution than to overall fat mass. Both perirenal fat and epicardial fat are visceral fat depots surrounding the kidneys and the myocardium, respectively, which can be easily assessed by ultrasound. Their clinical relevance in children is largely unknown. This review describes studies relating perirenal and epicardial fat to cardiovascular disease or carotid intima-media thickness (cIMT), a well-established surrogate for subclinical atherosclerosis, and discusses this in context with our own data from children. In adults, both perirenal and epicardial fat are useful biological markers of visceral obesity. The former has been related to hypertension in overweight subjects and with atherosclerosis in patients with human immunodeficiency virus. The latter was associated with several metabolic syndrome components and with calcification of the carotid artery. In healthy prepubertal children, both epicardial and perirenal fat thickness, rather than total body fat mass, were related to cIMT. Ultrasonography measures of perirenal and epicardial fat are related to atherosclerosis in adults and may be convenient tools for the assessment of cardiometabolic risk in children.
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참고문헌 (41)
참고문헌 신청
Must A / 1992 / Longterm morbidity and mortality of overweight adolescents. A follow-up of the Harvard Growth Study of 1922 to 1935 / N Engl J Med 327:1350~1355
Lorenz MW / 2007 / Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and metaanalysis / Circulation 115:459~467
Brady TM / 2012 / Carotid intima-media thickness in children with CKD: results from the CKiD study / Clin J Am Soc Nephrol 7:1930~1937
Celermajer DS / 2006 / Childhood risk factors for adult cardiovascular disease and primary prevention in childhood / Heart 92:1701~1706
Després JP / 2012 / Body fat distribution and risk of cardiovascular disease: an update / Circulation 126:1301~1313
Lorenz MW / 2007 / Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and metaanalysis / Circulation 115:459~467
Brady TM / 2012 / Carotid intima-media thickness in children with CKD: results from the CKiD study / Clin J Am Soc Nephrol 7:1930~1937
Celermajer DS / 2006 / Childhood risk factors for adult cardiovascular disease and primary prevention in childhood / Heart 92:1701~1706
Després JP / 2012 / Body fat distribution and risk of cardiovascular disease: an update / Circulation 126:1301~1313
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