지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.4
- 수록면
- 87 - 101 (15page)
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초록· 키워드
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Receptor-interacting serine/threonine-protein kinase (RIPK) 3 is a member of the TNF receptor-I signaling complex and mediates necroptosis, an inflammatory cell death. Ulcerative colitis (UC) is an excessive inflammatory disease caused by uncontrolled T cell activation. The current study is aimed to determine whether RIPK3 inhibitor attenuates UC development inhibiting inflammation and necroptosis using experimental colitis mice model. Dextran sulfate sodium-induced colitis mice were administered RIPK3 inhibitor (3 mg/ml) 3 times and their tissues were analyzed by immunohistochemistry. RIPK3, mixed lineage kinase domain-like (MLKL), phosphorylated MLKL, IL-17, and CD4 in colitis patient colon tissues were detected using confocal microscopy. Protein levels were measured using immunohistochemistry and ELISA. The differentiation of Th17 cells was evaluated using flow cytometry. The expression of proinflammatory cytokines and necroptosis in peripheral blood mononuclear cells from UC patients was decreased markedly by RIPK3 inhibitor treatment. We also observed that the injection of RIPK3 inhibitor improves colitis severity and protects intestinal destruction. RIPK3 inhibitor reduced necroptosis factors and proinflammatory cytokines in the colon and consequently protected colon devastation. The expression of inflammatory mediators in experimental colitis mice splenocytes was decreased significantly by RIPK3 inhibitor treatment. These results suggest that RIPK3 inhibitor ameliorates severity of experimental colitis and reduces inflammation through the inhibition of inflammatory response and necroptosis and support RIPK3-targeting substances for treatment of UC.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (25)
참고문헌 신청
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Pasparakis M / 2015 / Necroptosis and its role in inflammation / Nature 517:311~320
Vandenabeele P / 2010 / Molecular mechanisms of necroptosis : an ordered cellular explosion / Nat Rev Mol Cell Biol 11:700~714
Linkermann A / 2014 / Necroptosis / N Engl J Med 370:455~465
Vanden Berghe T / 2014 / Regulated necrosis : the expanding network of non-apoptotic cell death pathways / Nat Rev Mol Cell Biol 15:135~147
Pasparakis M / 2015 / Necroptosis and its role in inflammation / Nature 517:311~320
Vandenabeele P / 2010 / Molecular mechanisms of necroptosis : an ordered cellular explosion / Nat Rev Mol Cell Biol 11:700~714
Linkermann A / 2014 / Necroptosis / N Engl J Med 370:455~465
Vanden Berghe T / 2014 / Regulated necrosis : the expanding network of non-apoptotic cell death pathways / Nat Rev Mol Cell Biol 15:135~147
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Cytokine Expression of Microscopic Colitis Including Interleukin-17
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UCI(KEPA) : I410-ECN-0101-2020-517-000894435