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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2019.11
- 수록면
- 1,733 - 1,736 (4page)
이용수
초록· 키워드
오류제보하기
Three-dimensional (3D) cell culture systems and microfluidic systems are being studied as systems with better biocompatibility than 2D cell culture systems, respectively. Integrating these two systems, we propose a system that can apply different shear stresses to 3D multicellular spheroid grown in one channel. The shape of the microfluidic channel was designed in a semicircular shape for the gradient distribution of shear stress, and the microwell array was placed on the bottom of the channel for 3D cell culture. The computational simulation confirmed that different shear stresses were applied to the spheroids placed in each microwell array, which may be useful as a reference for future work. We have also successfully fabricated a system of PDMS materials from a mold made by a CNC milling machine. This system allows for observing biological changes in spheroid caused by the shear stress and can be utilized as a system having better biocompatibility.
목차
Abstract
1. Introduction
2. Methods
3. Results and discussions
4. Conclusion
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