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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.3
- 수록면
- 229 - 237 (9page)
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초록· 키워드
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Background: We investigated the tolerability and pharmacokinetic properties of various ginsenosides, including Rb1, Rb2, Rc, Rd, and compound K, after single or multiple administrations of red ginseng extract in human beings.
Methods: Red ginseng extract (dried ginseng > 60%) was administered once and repeatedly for 15 days to 15 healthy Korean people. After single and repeated administration of red ginsengextract, blood sample collection, measurement of blood pressure and body temperature, and routine laboratory test were conducted over 48-h test periods.
Results: Repeated administration of high-dose red ginseng for 15 days was well tolerated and did not produce significant changes in body temperature or blood pressure. The plasma concentrations of Rb1, Rb2, and Rc were stable and showed similar area under the plasma concentration-time curve (AUC) values after 15 days of repeated administration. Their AUC values after repeated administration of red ginseng extract for 15 days accumulated 4.5- to 6.7-fold compared with single-dose AUC. However, the plasma concentrations of Rd and compound K showed large interindividual variations but correlated well between AUC of Rd and compound K. Compound K did not accumulate after 15 days of repeated administration of red ginseng extract.
Conclusion: A good correlation between the AUC values of Rd and compound K might be the result of intestinal biotransformation of Rb1, Rb2, and Rc to Rd and subsequently to compound K, rather than the intestinal permeability of these ginsenosides. A strategy to increase biotransformation or reduce metabolic intersubject variability may increase the plasma concentrations of Rd and compound K.
Methods: Red ginseng extract (dried ginseng > 60%) was administered once and repeatedly for 15 days to 15 healthy Korean people. After single and repeated administration of red ginsengextract, blood sample collection, measurement of blood pressure and body temperature, and routine laboratory test were conducted over 48-h test periods.
Results: Repeated administration of high-dose red ginseng for 15 days was well tolerated and did not produce significant changes in body temperature or blood pressure. The plasma concentrations of Rb1, Rb2, and Rc were stable and showed similar area under the plasma concentration-time curve (AUC) values after 15 days of repeated administration. Their AUC values after repeated administration of red ginseng extract for 15 days accumulated 4.5- to 6.7-fold compared with single-dose AUC. However, the plasma concentrations of Rd and compound K showed large interindividual variations but correlated well between AUC of Rd and compound K. Compound K did not accumulate after 15 days of repeated administration of red ginseng extract.
Conclusion: A good correlation between the AUC values of Rd and compound K might be the result of intestinal biotransformation of Rb1, Rb2, and Rc to Rd and subsequently to compound K, rather than the intestinal permeability of these ginsenosides. A strategy to increase biotransformation or reduce metabolic intersubject variability may increase the plasma concentrations of Rd and compound K.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (30)
참고문헌 신청
Choi KT / 2008 / Botanical characteristics, pharmacological effects and medicinal components of korean panax ginseng c a meyer / Acta Pharmacol Sin 29:1109~1118
이상명 / 2015 / Characterization of Korean Red Ginseng (Panax ginseng Meyer): History, preparation method, and chemical composition / Journal of Ginseng Research 39(4):384~391
Kim MG / 2016 / Effect of fermented red ginseng on cytochrome p450 and p-glycoprotein activity in healthy subjects, as evaluated using the cocktail approach / Br J Clin Pharmacol 82:1580~1590
Ru W / 2015 / Chemical constituents and bioactivities of panax ginseng(c. A. Mey.) / Drug Discov Ther 9:23~32
김지혜 / 2017 / Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases / Journal of Ginseng Research 41(4):435~443
이상명 / 2015 / Characterization of Korean Red Ginseng (Panax ginseng Meyer): History, preparation method, and chemical composition / Journal of Ginseng Research 39(4):384~391
Kim MG / 2016 / Effect of fermented red ginseng on cytochrome p450 and p-glycoprotein activity in healthy subjects, as evaluated using the cocktail approach / Br J Clin Pharmacol 82:1580~1590
Ru W / 2015 / Chemical constituents and bioactivities of panax ginseng(c. A. Mey.) / Drug Discov Ther 9:23~32
김지혜 / 2017 / Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases / Journal of Ginseng Research 41(4):435~443
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UCI(KEPA) : I410-ECN-0101-2020-524-000504475