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논문 기본 정보

자료유형
학술저널
저자정보
Shin, Jae-Hoon (Kwangwoon University) Park, Jae-Ho (Kwangwoon University) Park, Sok (Kwangwoon University)
저널정보
한국체육과학회 한국체육과학회지 한국체육과학회지 제29권 제1호 (자연과학 편)
발행연도
2020.2
수록면
735 - 744 (10page)
DOI
10.35159/kjss.2020.02.29.1.735

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초록· 키워드

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We investigated the effect of regular aerobic exercise on colon tumorigenesis associated with inflammatory factors, such as interleukin-1β(IL-1β), interleukin-6 (IL-6), monocyte chemoatractant protein-1 (MCP-1) and tumor necrosis factor-α(TNF-α), in azoxymethan/dextran sulfate sodium (AOM/DSS) -administrated mice. ICR mice (5 weeks o ld) were divided into three g roups of 10 animals each, consisting of a control group (CON), an AOM/DSS treatment group (AOM/DSS), and an AOM/DSS treatment plus exercise group (AOM/DSS+Ex). The AOM/DSS+Ex group performed five times per week, for a total of 45 minutes, at a speed of 20 m per minute, using a treadmill with a gradient of 5% for 12 weeks. To investigate the effects of regular aerobic exercises on inflammation and formation of colorectal cancer, we carried out colorectal histopathologic analysis, colon tumor number counting and tumor-related inflammatory cytokine analysis. The number of colon tumors in the AOM/DSS+Ex group was approximately 25% lower than in the AOM/DSS group, but no statistically significant. In colon weight and length, there was no significantly difference between AOM/DSS group and AOM/DSS+Ex group. On the other hand, there were significant reductions in tumor-related inflammatory cytokines, IL-6 and TNF-α(P<.05) between AOM/DSS group and AOM/DSS+Ex group, but not in IL-1β and MCP-1. In conclusion, this exercise protocol resulted in partial anti-inflammatory and -tumor effects. Therefore, it is necessary to carry out further studies by diverse exercise protocols to establish colon cancer prevention program.

목차

Abstract
Ⅰ. Introduction
Ⅱ. Methods
Ⅲ. Results
Ⅳ. Discussion
Ⅴ. Conclusion
References

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UCI(KEPA) : I410-ECN-0101-2020-692-000424933