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논문 기본 정보

자료유형
학술저널
저자정보
Ji Hyun Moon (Konyang University) Jong Ho Park (Konyang University) Ji Heun Jeong (Konyang University) Nak Song Sung (Konyang University Hospital) Young Gil Jeong (Konyang University) Ki Chang Song (Konyang University) Jong Pil Ahn (Korea Institute of Ceramic Engineering and Technology) Nam-Seob Lee (Konyang University) Seung Yun Han (Konyang University)
저널정보
대한체질인류학회 해부·생물인류학 해부·생물인류학 제32권 제4호
발행연도
2019.12
수록면
129 - 139 (11page)

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이 논문의 연구 히스토리 (2)

2019

Metformin-loaded Citric Acid Cross-linked Agarose Films in the Prevention of Postoperative Abdominal Adhesion
Ji Hyun Moon ,  Jong Ho Pa ,  k 외 7명 해부·생물인류학 2019.12 학술저널
Metformin-loaded Citric Acid Cross-linked Agarose Films in the Prevention of Postoperative Abdominal Adhesion
Ji Hyun Moon ,  Jong Ho Pa ,  k 외 9명 대한체질인류학회 학술대회 연제 초록 2019.05 학술대회자료

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Postoperative abdominal adhesion (PAA) causes significant long-term postoperative morbidity. Although numerous physical anti-adhesion barriers (AAB) are used as therapeutical interventions, none of them has achieved sustained success. As a potential strategy to overcome the limitations, drug-eluting AAB have attracted scientific attention. Here, we produced agar films (AF) chemically cross-linked with different concentrations of citric acid (CA) and we measured the physicochemical properties such as crosslinking strength, swelling ratio, hydrophilicity, and biodegradability of the yielded CA-AFs. Next, Metformin (MET), an antidiabetic drug with anti-proliferative and anti-inflammatory properties, was loaded in the CA-AFs yielding the MET-loaded CA-AF (MET@CA-AF) and the time-dependent MET release was monitored. Based on their physicochemical properties, MET@CA-AF containing 20% CA appeared a promising AAB candidate and was further used in an in vivo study. Mouse models of PAA were established with cecum abrasion and the MET@CAAF and CA-AF were applied between the injured interfaces. At postoperative day 14, the therapeutic efficacies were analyzed by using clinical adhesion scoring and quantification of collagen-I and fibroblasts in adhesion interfaces. The results showed that applications of MET@CA-AF or CA-AF for 14 days significantly attenuated the clinical adhesion score and thickness of adhesion interface. Furthermore, when compared with the group with operation, the groups with MET@CA-AF or CA-AF exhibited the significant attenuation in PAA-associated myofibroblast activation in adhesion interface. Importantly, these attenuations were significantly more intensified in the group with MET@CA-AF than in the group with CA-AF. Based on our data, we anticipate that MET@CAAF, a novel synthesized drug-eluting AAB, can protect against PAA by exerting the dual role of physical barrier and MET-based pharmaceutic.
#Agarose #Anti-adhesion barriers #Metformin #Postoperative abdominal adhesion

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INTRODUCTION
Abstract
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

참고문헌 (45)

참고문헌 신청
Tabibian N / 2017 / Abdominal adhesions : a practical review of an often overlooked entity / Ann Med Surg(Lond) 15:9~13 google schola Van Goor H / 2007 / Consequences and complications of peritoneal adhesions / Colorectal Dis 9:25~34 google schola Cohen Z / 2005 / Prevention of postoperative abdominal adhesions by a novel, glycerol/sodium hyaluronate/carboxymethylcellulose-based bioresorbable membrane : a prospective, randomized, evaluator-blinded multicenter study / Dis Colon Rectum 48:1130~1139 google schola Tabchouri N / 2018 / Only surgical treatment to be considered for adhesive small bowel obstruction : a new paradigm / Gastroenterol Res Pract 2018:9628490 google schola Lin LX / 2017 / Evaluation of surgical anti-adhesion products to reduce postsurgical intra-abdominal adhesion formation in a rat model / PLoS One 12:e0172088 google schola

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