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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제4호
- 발행연도
- 2019.1
- 수록면
- 596 - 606 (11page)
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초록· 키워드
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N-acyl-homoserine lactone quorum sensing (AHL-QS) has been shown to regulate many physiological behaviors in Serratia marcescens MG1. In the current study, the effects of AHL-QS on the biosynthesis of acid and neutral products by S. marcescens MG1 and its isogenic ΔswrI with or without supplementing exogenous N-hexanoyl-L-homoserine lactone (C6-HSL) were systematically investigated. The results showed that swrI disruption resulted in rapid pH drops from 7.0 to 4.8, which could be restored to wild type by supplementing C6-HSL. Furthermore, fermentation product analysis indicated that ΔswrI could lead to obvious accumulation for acidogenesis products such as lactic acid and succinic acid, especially excess acetic acid (2.27 g/l) produced at the early stage of fermentation, whereas solventogenesis products by ΔswrI appeared to noticeably decrease by an approximate 30% for acetoin during 32-48 h and by an approximate 20% for 2,3-butanediol during 24-40 h, when compared to those by wild type. Interestingly, the excess acetic acid produced could be removed in an AHL-QS-independent manner. Subsequently, quantitative real-time PCR was used to determine the mRNA expression levels of genes responsible for acidogenesis and solventogenesis and showed consistent results with those of product synthesis. Finally, by close examination of promoter regions of the analyzed genes, four putative luxI box-like motifs were found upstream of genes encoding acetyl-CoA synthase, lactate dehydrogenase, α-acetolactate decarboxylase, and Lys-like regulator. The information from this study provides a novel insight into the roles played by AHL-QS in switching from acidogenesis to solventogenesis in S. marcescens MG1.
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참고문헌 (33)
참고문헌 신청
Papenfort K / 2016 / Quorum sensing signalresponse systems in Gram-negative bacteria / Nat. Rev. Microbiol 14:576~588
Whiteley M / 2017 / Progress in and promise of bacterial quorum sensing research / Nature 551:313~320
Abisado RG / 2018 / Bacterial quorum sensing and microbial community interactions / MBio 9
Zhou J / 2016 / Quorum sensing is a language of chemical signals and plays an ecological role in algal-bacterial interactions / CRC Crit. Rev. Plant Sci 35:81~105
Mangwani N / 2016 / Bacterial biofilms and quorum sensing : fidelity in bioremediation technology / Biotechnol. Genet. Eng. Rev 32:43~73
Whiteley M / 2017 / Progress in and promise of bacterial quorum sensing research / Nature 551:313~320
Abisado RG / 2018 / Bacterial quorum sensing and microbial community interactions / MBio 9
Zhou J / 2016 / Quorum sensing is a language of chemical signals and plays an ecological role in algal-bacterial interactions / CRC Crit. Rev. Plant Sci 35:81~105
Mangwani N / 2016 / Bacterial biofilms and quorum sensing : fidelity in bioremediation technology / Biotechnol. Genet. Eng. Rev 32:43~73
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