지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 343 - 352 (10page)
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초록· 키워드
오류제보하기
Purpose: To evaluate the efficacy and safety of cyclosporine nanoemulsion 0.05% compared to cyclosporine emulsion0.05% and diquafosol sodium 3%. Methods: This was a multicenter, randomized, evaluator-masked, active control, parallel, phase IV study. A total of227 patients were randomly allocated to instill cyclosporine nanoemulsion 0.05% (CN) twice daily, cyclosporineemulsion 0.05% (CE) twice daily, or diquafosol sodium 3% (DQ) six times daily. Non-inferiority of CN was analyzedby primary endpoint (cornea and conjunctival staining scores at week 12). The secondary endpoints were scoresof corneal staining, conjunctival staining, tear break-up time, Schirmer test, and Ocular Surface Disease Index atweeks 4 and 12. Results: Primary endpoints showed statistically significant improvements in all groups. Primary endpoints were -6.60for the CN group, -5.28 for the CE group, and -6.63 for the DQ group (National Eye Institute scale from 0 to 33), verifyingthe non-inferiority of CN compared to CE (95% confidence interval, -0.15 to 2.80, Δ>-2.88). In intergroup comparisonbetween CN and CE groups, the CN group had significantly more decreased conjunctival staining score atweek 12. Intergroup comparison between CN and DQ groups showed consistent statistically significant improvementsin TBUT and Schirmer test in the CN group. In the DQ group, TBUT showed late statistically significant improvementat week 12 and Schirmer test showed relatively short-term statistically significant improvement at week 4. Conclusions: Cyclosporine nanoemulsion 0.05% was equivalently efficient compared to cyclosporine emulsion 0.05%and diquafosol sodium 3%. In addition, CN showed significant improvements in several parameters for treatment ofdry eyes.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
2007 / Management and therapy of dry eye disease: report of the Management and Therapy Subcommittee of the International Dry Eye WorkShop (2007) / Ocul Surf 5:163~178
Fruman DA / 1992 / Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A / Proc Natl Acad Sci U S A 89:3686~3690
Yeh S / 2003 / Apoptosis of ocular surface cells in experimentally induced dry eye / Invest Ophthalmol Vis Sci 44:124~129
Waldmeier PC / 2003 / Cyclophilin D as a drug target / Curr Med Chem 10:1485~1506
Czogalla A / 2009 / Oral cyclosporine A : the current picture of its liposomal and other delivery systems / Cell Mol Biol Lett 14:139~152
Fruman DA / 1992 / Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A / Proc Natl Acad Sci U S A 89:3686~3690
Yeh S / 2003 / Apoptosis of ocular surface cells in experimentally induced dry eye / Invest Ophthalmol Vis Sci 44:124~129
Waldmeier PC / 2003 / Cyclophilin D as a drug target / Curr Med Chem 10:1485~1506
Czogalla A / 2009 / Oral cyclosporine A : the current picture of its liposomal and other delivery systems / Cell Mol Biol Lett 14:139~152
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