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논문 기본 정보
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- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제49권 제1호
- 발행연도
- 2019.1
- 수록면
- 37 - 44 (8page)
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The effects of salt forming agents for chitosan on the potential for nanoparticle formation was investigated. The salt forms were prepared from the amino acid group, including glutamic and aspartic acids, and the alpha hydroxyl acid group, including lactic and glycolic acids. All types of chitosan salt could be used to prepare bovine serum albumin (BSA) loaded nanoparticles. The chitosan salts prepared from the amino acid group showed a higher salt formation ability as demonstrated using FTIR, hence a higher %encapsulation efficiency (%EE) and a reduction in zeta potential were obtained. The difference was due to the different organic acids used giving different polymer conformations and pH values in solution. Chitosan glutamate gave the highest salt formation ability and hence the highest %EE was obtained. The release of protein from all types of chitosan was similar and chitosan glutamate exhibited the highest release. Chitosan salt is therefore a material of choice for protein-loaded nanoparticles and the characteristics of nanoparticles can be readily modulated by different types of salt form.
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참고문헌 (38)
참고문헌 신청
Agnihotri S / 2004 / Recent advances on chitosan-based micro and nanoparticles in drug delivery / J Control Release 100:5~28
Ahsan F / 2002 / Targeting to macrophages : role of physicochemical properties of particulate carriers—liposomes and microspheres—on the phagocytosis by macrophages / J Control Release 79(1):29~40
Boonsongrit Y / 2008 / Characterization of drug-chitosan interaction by 1H NMR, FTIR and isothermal titration calorimetry / Eur J Pharm Sci 69(1):388~395
Calvo P / 1997 / Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers / Pharm Res 14:1431~1436
Casettari L / 2014 / Chitosan in nasal delivery systems for therapeutic drugs / J Control Release 190:189~200
Ahsan F / 2002 / Targeting to macrophages : role of physicochemical properties of particulate carriers—liposomes and microspheres—on the phagocytosis by macrophages / J Control Release 79(1):29~40
Boonsongrit Y / 2008 / Characterization of drug-chitosan interaction by 1H NMR, FTIR and isothermal titration calorimetry / Eur J Pharm Sci 69(1):388~395
Calvo P / 1997 / Novel hydrophilic chitosan-polyethylene oxide nanoparticles as protein carriers / Pharm Res 14:1431~1436
Casettari L / 2014 / Chitosan in nasal delivery systems for therapeutic drugs / J Control Release 190:189~200
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