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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 77 - 80 (4page)
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Clear cell odontogenic carcinoma (CCOC), a very rare neoplasm located mostly in the mandible, has been regarded as a benign tumor. However, due to the accumulation of case reports, CCOC has been reclassified as a malignant entity by the World Health Organization. Patients with CCOC present with regional swelling and periodontal indications with variable pain, often remaining misdiagnosed for a long period. CCOC has slow growth but aggressive behavior, requiring radical resection. Histologic analysis revealed the monophasic, biphasic, and ameloblastic types of CCOC with clear cells and a mixed combination of polygonal and palisading cells. At the molecular level, CCOC shows the expression of cytokeratin and epithelial membrane antigen, along with markers that assign CCOC to the sarcoma family. At the genetic level, Ewing sarcoma breakpoint region 1-activating transcription factor 1 fusion is regarded as the key feature for identification. Nevertheless, the scarcity of cases and dependence on histological data delay the development of an efficient therapy. Regarding the high recurrence rate and the potential of distant metastasis, further characterization of CCOC is necessary for an early and accurate diagnosis.
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참고문헌 (29)
참고문헌 신청
Louis S. Hansen / 1985 / Clear cell odontogenic tumor— a new histologic variant with aggressive potential / Head & Neck Surgery 8(2):115~123
F.P.S. Guastaldi / 2019 / Clear cell odontogenic carcinoma: a rare jaw tumor. A summary of 107 reported cases / International Journal of Oral and Maxillofacial Surgery 48(11):1405~1410
John M. Wright / 2017 / Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Odontogenic and Maxillofacial Bone Tumors / Head and Neck Pathology 11(1):68~77
Adriano Mota Loyola / 2015 / Clear cell odontogenic carcinoma: report of 7 new cases and systematic review of the current knowledge / Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 120(4):483~496
Le Charpentier Y / 1994 / Classification of odontogenic tumors, 2nd edition (WHO, 1992) / Ann Pathol 14:55~57
F.P.S. Guastaldi / 2019 / Clear cell odontogenic carcinoma: a rare jaw tumor. A summary of 107 reported cases / International Journal of Oral and Maxillofacial Surgery 48(11):1405~1410
John M. Wright / 2017 / Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Odontogenic and Maxillofacial Bone Tumors / Head and Neck Pathology 11(1):68~77
Adriano Mota Loyola / 2015 / Clear cell odontogenic carcinoma: report of 7 new cases and systematic review of the current knowledge / Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 120(4):483~496
Le Charpentier Y / 1994 / Classification of odontogenic tumors, 2nd edition (WHO, 1992) / Ann Pathol 14:55~57
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