지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제7호
- 발행연도
- 2019.1
- 수록면
- 1,137 - 1,143 (7page)
이용수
초록· 키워드
오류제보하기
Hepatitis E virus (HEV) accounts for 20 million infections in humans worldwide. In most cases, the infections are self-limiting while HEV genotype 1 infection cases may lead to lethal infections in pregnant women (~ 20% fatality). The lack of small animal models has hampered detailed analysis of virus-host interactions and HEV-induced pathology. Here, by employing a recently developed culture-adapted HEV, we demonstrated that methyltransferase, a nonstructural protein, strongly inhibits melanoma differentiation-associated gene 5 (MDA5)- mediated activation of type I interferon responses. Compared to uninfected controls, HEVinfected cells display significantly lower levels of IFN-β promoter activation when assessed by luciferase assay and RT-PCR. HEV genome-wide screening showed that HEV-encoded methyltransferase (MeT) strongly inhibits MDA5-mediated transcriptional activation of IFN-β and NF-κB in a dose-responsive manner whether or not it is expressed in the presence/ absence of a tag fused to it. Taken together, current studies clearly demonstrated that HEV MeT is a novel antagonist of MDA5-mediated induction of IFN-β signaling.
목차
등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
Denner J / 2019 / Hepatitis E virus (HEV)-the future / Viruses 11(3):E251
Berke T / 2000 / Reclassification of the Caliciviridae into distinct genera and exclusion of hepatitis E virus from the family on the basis of comparative phylogenetic analysis / Arch. Virol 145:1421~1436
Kang HS / 2016 / Transgenic expression of non-structural genes of Theiler’s virus suppresses initial viral replication and pathogenesis of demyelination / J. Neuroinflammation 13:133
강상민 / 2017 / Host Innate Immunity against Hepatitis E Virus and Viral Evasion Mechanisms / Journal of Microbiology and Biotechnology 27(10):1727~1735
Purdy MA / 2010 / Evolutionary history and population dynamics of hepatitis E virus / PLoS One 5:e14376
Berke T / 2000 / Reclassification of the Caliciviridae into distinct genera and exclusion of hepatitis E virus from the family on the basis of comparative phylogenetic analysis / Arch. Virol 145:1421~1436
Kang HS / 2016 / Transgenic expression of non-structural genes of Theiler’s virus suppresses initial viral replication and pathogenesis of demyelination / J. Neuroinflammation 13:133
강상민 / 2017 / Host Innate Immunity against Hepatitis E Virus and Viral Evasion Mechanisms / Journal of Microbiology and Biotechnology 27(10):1727~1735
Purdy MA / 2010 / Evolutionary history and population dynamics of hepatitis E virus / PLoS One 5:e14376
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Hepatitis E Virus Methyltransferase Inhibits Type I Interferon Induction by Targeting RIG-I
Journal of Microbiology and Biotechnology
2018 .01
-
E형 간염 바이러스에 의한 제 1형 인터페론 신호전달분자 활성 억제
한국미생물·생명공학회지
2018 .01
-
Hepatitis E Virus Papain-Like Cysteine Protease Inhibits Type I Interferon Induction by Down-Regulating Melanoma Differentiation-Associated Gene 5
Journal of Microbiology and Biotechnology
2018 .01
-
Host Innate Immunity against Hepatitis E Virus and Viral Evasion Mechanisms
Journal of Microbiology and Biotechnology
2017 .01
-
Identification of Hepatitis E Virus in Bovine and Porcine Raw Livers
Journal of Microbiology and Biotechnology
2019 .01
-
The Simulation Process of Electromagnetic Field, Thermal and NVH for EV/HEV Traction Motor
한국자기학회 학술연구발표회 논문개요집
2020 .07
-
Influence of temperature on iron loss properties of non-grain-oriented electrical steel for HEV, EV traction motor
한국자기학회 학술연구발표회 논문개요집
2024 .05
-
친환경자동차 구동모터용 전기강판 및 이용 기술
한국자기학회 학술연구발표회 논문개요집
2015 .05
-
Experimental Infection of Hepatitis E Virus in Animal Models
한국미생물학회 학술대회논문집
2019 .04
-
Chikungunya Virus nsP2 Impairs MDA5/ RIG-I-Mediated Induction of NF-κB Promoter Activation: A Potential Target for Virus-Specific Therapeutics
Journal of Microbiology and Biotechnology
2020 .01
-
Zika Virus Proteins NS2A and NS4A Are Major Antagonists that Reduce IFN-β Promoter Activity Induced by the MDA5/RIG-I Signaling Pathway
Journal of Microbiology and Biotechnology
2019 .01
-
Hepatitis C Virus Nonstructural Protein 5A Interacts with Immunomodulatory Kinase IKKε to Negatively Regulate Innate Antiviral Immunity
Molecules and Cells
2022 .10
-
O- and N-Methyltransferases in benzylisoquinoline alkaloid producing plants
Genes & Genomics
2024 .03
-
Regulation of MDA5-MAVS Antiviral Signaling Axis by TRIM25 through TRAF6-Mediated NF-κB Activation
Molecules and Cells
2015 .09
-
Recent Advances in Understanding and Cure for Hepatitis B Virus Infection
한국미생물학회 학술대회논문집
2019 .04
-
Modulation of the IFN-β and NF-κB Signaling Pathways by Chikungunya Virus-encoded Genes
한국미생물학회 학술대회논문집
2020 .10
-
Chikungunya Virus-Encoded nsP2, E2 and E1 Strongly Antagonize the Interferon-β Signaling Pathway
Journal of Microbiology and Biotechnology
2019 .01
-
Middle East Respiratory Syndrome Coronavirus-Encoded Accessory Proteins Impair MDA5-and TBK1-Mediated Activation of NF-κB
Journal of Microbiology and Biotechnology
2019 .01
-
Zika Virus-Encoded NS2A and NS4A Strongly Downregulate NF-κB Promoter Activity
Journal of Microbiology and Biotechnology
2020 .01
-
A Homogeneous Immunoassay Method for Detecting Interferon-Gamma in Patients with Latent Tuberculosis Infection
Journal of Microbiology and Biotechnology
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0