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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제6호
- 발행연도
- 2019.1
- 수록면
- 897 - 904 (8page)
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초록· 키워드
오류제보하기
Monascus purpureus recombinant mppC and mpp7 knockout strains were subjected to extractive fermentation in the context of azaphilone pigment production. Inclusion of Diaion HP-20 resin resulted in the selective production of unreduced azaphilone congeners, in addition to the early intermediate FK17-P2a, from ΔmppC and Δmpp7 strains that would otherwise mainly produce reduced congeners. Structural determination of two novel unreduced azaphilones from the Δmpp7 strain was accomplished. The unreduced azaphilone compound was converted into the cognate reduced congener in recombinant M. purpureus strains, demonstrating its intermediate role in azaphilone biosynthesis. This study demonstrates the possibility that extractive fermentation with Diaion HP-20 resin can be used to obtain cryptic azaphilone metabolites.
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참고문헌 (30)
참고문헌 신청
Wang TH / 2007 / Monascus rice products / Adv. Food Nutr. Res 53:123~159
Feng Y / 2012 / Monascus pigments / Appl. Microbiol. Biotechnol 96:1421~1440
Patakova P / 2013 / Monascus secondary metabolites : production and biological activity / J. Ind. Microbiol. Biotechnol 40:169~181
Gao JM / 2013 / Azaphilones : chemistry and biology / Chem. Rev 113:4755~4811
Chen W / 2015 / Edible filamentous fungi from the species Monascus : early traditional fermentations, modern molecular biology, and future genomics / Compr. Rev. Food Sci. Food Saf 14:555~567
Feng Y / 2012 / Monascus pigments / Appl. Microbiol. Biotechnol 96:1421~1440
Patakova P / 2013 / Monascus secondary metabolites : production and biological activity / J. Ind. Microbiol. Biotechnol 40:169~181
Gao JM / 2013 / Azaphilones : chemistry and biology / Chem. Rev 113:4755~4811
Chen W / 2015 / Edible filamentous fungi from the species Monascus : early traditional fermentations, modern molecular biology, and future genomics / Compr. Rev. Food Sci. Food Saf 14:555~567
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