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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제5호
- 발행연도
- 2019.1
- 수록면
- 739 - 748 (10page)
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초록· 키워드
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Cheonggukjang and chaga mushrooms have numerous health benefits, and have been used in alternative medicine. Therefore, a powder mixture of 98: Cheonggukjang and 2: Chaga extracts was fermented with Lactobacillus acidophilus KCTC3925 (FCC) and its anti-obesity effects in high-fat diet (HFD)-induced obese mice were determined. Five-week-old male ICR mice were fed a normal diet or HFD in the presence or absence of 3% and 5% FCC by weight (n = 10 per group). After 12 weeks, the mice were sacrificed, and the serum and tissue samples were collected for analysis. Body weight and epididymal fat pad weight were significantly lowered in the 3% and 5% FCC groups compared with those in the HFD control group (p < 0.01). FCC supplementation suppressed serum triglyceride and increased serum HDL-C levels (p < 0.01). Serum GOT, GPT, and leptin levels, hepatic COX-2 mRNA expression, and splenic COX-2 and IL-4 mRNA expression were significantly higher in the HFD groups than in the control group (p > 0.05); however, except for splenic IL-4 levels, the increases were significantly attenuated by FCC supplementation. Expression of ICAM-1, an aortic inflammatory marker, was significantly increased in the HFD group; this effect was suppressed in the 3% FCC group (p < 0.01) but not in the 5% FCC group. FCC suppressed the body weight and epididymal fat pad weight gain, as well as inflammatory responses in the liver and spleen of HFD-fed mice. Thus, FCC supplementation will be beneficial for the treatment of obesity-related effects.
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참고문헌 (47)
참고문헌 신청
Hotamisligil GS / 1993 / Adipose expression of tumor necrosis factor-alpha : direct role in obesity-linked insulin resistance / Science 259:87~91
Hotamisligil GS / 2006 / Inflammation and metabolic disorders / Nature 444:860~867
Duan Y / 2018 / Inflammatory links between high fat diets and diseases / Front. Immunol 9:2649
Ganesan K / 2018 / Anti-obesity effects of medicinal and edible mushrooms / Molecules 23:2880
Koh KK / 2005 / Inflammatory markers and the metabolic syndrome : insights from therapeutic interventions / J. Am. Coll. Cardiol 46:1978~1985
Hotamisligil GS / 2006 / Inflammation and metabolic disorders / Nature 444:860~867
Duan Y / 2018 / Inflammatory links between high fat diets and diseases / Front. Immunol 9:2649
Ganesan K / 2018 / Anti-obesity effects of medicinal and edible mushrooms / Molecules 23:2880
Koh KK / 2005 / Inflammatory markers and the metabolic syndrome : insights from therapeutic interventions / J. Am. Coll. Cardiol 46:1978~1985
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