지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1 - 12 (12page)
이용수
초록· 키워드
오류제보하기
Pulmonary fibrosis is a progressive disease characterized by epithelial cell damage, fibroblast proliferation, excessive extracellular matrix (ECM) deposition, and lung tissue scarring. Melatonin, a hormone produced by the pineal gland, plays an important role in multiple physiological and pathological responses in organisms. However, the function of melatonin in the development of bleomycin-induced pulmonary injury is poorly understood. In the present study, we found that melatonin significantly decreased mortality and restored the function of the alveolar epithelium in bleomycin-treated mice. However, pulmonary function mainly depends on type II alveolar epithelial cells (AECIIs) and is linked to mitochondrial integrity. We also found that melatonin reduced the production of reactive oxygen species (ROS) and prevented apoptosis and senescence in AECIIs. Luzindole, a nonselective melatonin receptor antagonist, blocked the protective action of melatonin. Interestingly, we found that the expression of apelin 13 was significantly downregulated in vitro and in vivo and that this downregulation was reversed by melatonin. Furthermore, ML221, an apelin inhibitor, disrupted the beneficial effects of melatonin on alveolar epithelial cells. Taken together, these results suggest that melatonin alleviates lung injury through regulating apelin 13 to improve mitochondrial dysfunction in the process of bleomycin-induced pulmonary injury.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Inhibiting nighttime melatonin and boosting cortisol increase patrolling monocytes, phagocytosis, and myelination in a murine model of multiple sclerosis
Experimental and Molecular Medicine
2023 .01
-
Melatonin Suppression under LED Lighting Focused on Spectral Power Distribution Differences
조명·전기설비학회논문지
2015 .08
-
Inhibition of Proinflammatory Cytokines and Phagocytosis by Melatonin in LPS-Stimulated Microglia
한국생물공학회 학술대회
2017 .04
-
The Role of Nanospheres Loaded with Melatonin in the Improving of the Migration and Recovery Process of Inflammatory Bowel Disease
한국생물공학회 학술대회
2021 .10
-
Melatonin stimulates aromatase expression and estradiol production in human granulosa-lutein cells: relevance for the high serum estradiol levels in ovarian hyperstimulation syndrome
Experimental and Molecular Medicine
2020 .08
-
Melatonin Nanospheres Inhibit the Phosphorylation of p38 MAPK and NF-κB Responsible for the Gut Apoptosis and Autophagy in Induced by V. vulnificus VvpE
한국생물공학회 학술대회
2021 .04
-
Melatonin and doxorubicin synergistically enhance apoptosis via autophagy-dependent reduction of AMPKα1 transcription in human breast cancer cells
Experimental and Molecular Medicine
2021 .09
-
Melatonin prevents doxorubicin-induced cardiotoxicity through suppression of AMPKα2-dependent mitochondrial damage
Experimental and Molecular Medicine
2020 .12
-
YAP1 inhibits the senescence of alveolar epithelial cells by targeting Prdx3 to alleviate pulmonary fibrosis
Experimental and Molecular Medicine
2024 .07
-
Gold Nanoparticle Conjugated BSA Nano-Dots Decorated Poly-Lysine Interface for the Selective Voltammetry Detection of Melatonin
한국고분자학회 학술대회 연구논문 초록집
2024 .09
-
Erratum : Inhibiting nighttime melatonin and boosting cortisol increase patrolling monocytes, phagocytosis, and myelination in a murine model of multiple sclerosis
Experimental and Molecular Medicine
2023 .02
-
The Effects of a Combination of Rosa multiflora and Zizyphus jujuba on Sleep Quality in Anesthesia-induced Mice, Indicating an Enhancement in Sleep Quality
한국생물공학회 학술대회
2023 .04
-
일출일몰 데이터를 이용한 인간 중심 조명 구현에 관한 연구
전기전자재료학회논문지
2024 .09
-
Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway
Experimental and Molecular Medicine
2020 .12
-
Histone deacetylase 3 promotes alveolar epithelial–mesenchymal transition and fibroblast migration under hypoxic conditions
Experimental and Molecular Medicine
2022 .07
-
Histological and Physiological Studies of the Effect of Bone Marrow-Derived Mesenchymal Stem Cells on Bleomycin Induced Lung Fibrosis in Adult Albino Rats
조직공학과 재생의학
2021 .01
-
Automatic Signal-enhancement Lateral Flow Immunoassay for User-friendly Detection of Human Salivary Hormone
한국생물공학회 학술대회
2024 .09
-
MicroRNA Expression Analysis of Human Pulmonary Fibroblasts Treated with Acrolein
BioChip Journal
2018 .01
-
Emerging perspectives on mitochondrial dysfunction and inflammation in Alzheimer’s disease
BMB Reports
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0