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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 73 - 79 (7page)
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Purpose The aim of this study is to evaluate the prognostic significance of paranasal sinus invasion for nasopharyngeal carcinoma (NPC) and its suitable position in the T classification. Materials and Methods The magnetic resonance imaging (MRI) scans of 695 patients with previously untreated, biopsy-proven, non-metastatic NPC that was treated with intensity-modulated radiotherapy (IMRT) were reviewed retrospectively. Results The incidence of paranasal sinus invasion was 39.4% (274 of 695 patients). Multivariate analysis showed that paranasal sinus invasion was an independent negative prognostic factor for local failure-free survival (LFFS) (p < 0.05). According to the eighth American Joint Committee on Cancer (AJCC) staging system, 275 patients were classified as T3 classification. Of these, 78 patients (28.4%) developed paranasal sinus invasion (T3b) and 197 (71.6%) didn’t (T3a). The estimated 5-year LFFS and overall survival (OS) rates for the patients with T3b and T3a classification were 88.6% versus 95.0% (p=0.047), and 84.5% versus 93.3% (p=0.183), respectively. The estimated 5-year LFFS and OS rates for the patients with T4 classification were 89.5% and 83.2%, which were similar with the outcomes of patients with T3b classification. Conclusion MRI-determined paranasal sinus invasion is an independent prognostic factor of NPC treated by IMRT. Paranasal sinus invasion is recommended to classify as T4 classification in the 8th AJCC staging system for NPC.
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참고문헌 (20)
참고문헌 신청
International Agency for Research on Cancer / 2012 / GLOBOCAN 2012: estimated cancer incidence, mortality and prevalence worldwide in 2012 / IARC Press
Amin MB / 2017 / AJCC cancer staging manual / Springer
Pan JJ / 2016 / Proposal for the 8th edition of the AJCC/UICC staging system for nasopharyngeal cancer in the era of intensity-modulated radiotherapy / Cancer 122:546~558
Chinese Committee for Staging of Nasopharyngeal Carcinoma / 2013 / Report on revision of the Chinese 1992 staging system for nasopharyngeal carcinoma / J Radiat Oncol 2:233~240
Caineng Cao / 2017 / Magnetic Resonance Imaging–Detected Intracranial Extension in the T4 Classification Nasopharyngeal Carcinoma with Intensity-Modulated Radiotherapy / Cancer Research and Treatment 49(2):518~525
Amin MB / 2017 / AJCC cancer staging manual / Springer
Pan JJ / 2016 / Proposal for the 8th edition of the AJCC/UICC staging system for nasopharyngeal cancer in the era of intensity-modulated radiotherapy / Cancer 122:546~558
Chinese Committee for Staging of Nasopharyngeal Carcinoma / 2013 / Report on revision of the Chinese 1992 staging system for nasopharyngeal carcinoma / J Radiat Oncol 2:233~240
Caineng Cao / 2017 / Magnetic Resonance Imaging–Detected Intracranial Extension in the T4 Classification Nasopharyngeal Carcinoma with Intensity-Modulated Radiotherapy / Cancer Research and Treatment 49(2):518~525
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