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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제8호
- 발행연도
- 2019.1
- 수록면
- 1,221 - 1,229 (9page)
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Mycobacterium tuberculosis, a causative pathogen of tuberculosis (TB), still threatens human health worldwide. To find a novel drug to eradicate this pathogen, we tested taurine-5- bromosalicylaldehyde Schiff base (TBSSB) as an innovative anti-mycobacterial drug using Mycobacterium smegmatis as a surrogate model for M. tuberculosis. We investigated the antimicrobial activity of TBSSB against M. smegmatis by plotting growth curves, examined the effect of TBSSB on biofilm formation, observed morphological changes by scanning electron microscopy and transmission electron microscopy, and detected differentially expressed proteins using two-dimensional gel electrophoresis coupled with mass spectrometry. TBSSB inhibited mycobacterial growth and biofilm formation, altered cell ultrastructure and intracellular content, and inhibited cell division. Furthermore, M. smegmatis adapted itself to TBSSB inhibition by regulating the metabolic pathways and enzymatic activities of the identified proteins. NDMA-dependent methanol dehydrogenase, NAD(P)H nitroreductase, and amidohydrolase AmiB1 appear to be pivotal factors to regulate the M. smegmatis survival under TBSSB. Our dataset reinforced the idea that Schiff base-taurine compounds have the potential to be developed as novel anti-mycobacterial drugs.
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등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Organization WH / GLOBAL TUBERCULOSIS REPORT 2018
Rîmbu C / 2014 / Antibacterial activity of Pd(II) complexes with salicylaldehyde-amino acids Schiff bases ligands / Chem. Pharm. Bull. (Tokyo) 62:12~15
Chaudhary NK / 2017 / Metal complexes of a novel schiff base based on penicillin: characterization, molecular modeling, and antibacterial activity study / Bioinorg. Chem. Appl 2017:6927675
Siddappa K / 2014 / Synthesis, spectroscopic characterization, and biological evaluation studies of 5bromo-3-(((hydroxy-2-methylquinolin-7-yl)methylene)hydrazono) indolin-2-one and its metal (II) complexes / Bioinorg. Chem. Appl 2014:483282
Andiappan K / 2018 / In vitro cytotoxicity activity of novel Schiff base ligand-lanthanide complexes / Sci. Rep 8(1):3054
Rîmbu C / 2014 / Antibacterial activity of Pd(II) complexes with salicylaldehyde-amino acids Schiff bases ligands / Chem. Pharm. Bull. (Tokyo) 62:12~15
Chaudhary NK / 2017 / Metal complexes of a novel schiff base based on penicillin: characterization, molecular modeling, and antibacterial activity study / Bioinorg. Chem. Appl 2017:6927675
Siddappa K / 2014 / Synthesis, spectroscopic characterization, and biological evaluation studies of 5bromo-3-(((hydroxy-2-methylquinolin-7-yl)methylene)hydrazono) indolin-2-one and its metal (II) complexes / Bioinorg. Chem. Appl 2014:483282
Andiappan K / 2018 / In vitro cytotoxicity activity of novel Schiff base ligand-lanthanide complexes / Sci. Rep 8(1):3054
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