지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 150 - 157 (8page)
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초록· 키워드
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Purpose: Venous thromboembolism (VTE) is a serious complication that may occur after a major orthopedic surgery. The aim of the present study was to determine the necessity of a chemical thromboprophylactic agent (rivaroxaban [RXB]) by analyzing the prevalence of VTE in Korean arthroplasty patients who received RXB for prophylaxis compared with those who did not receive RXB. Materials and Methods: A total of 2,603 patients who underwent knee or hip arthroplasty between 1996 and 2017 were prospectively evaluated. Of these, 1,608 patients underwent surgery before January 2010 and were not administered any type of prophylaxis after surgery; the remaining 995 underwent surgery after 2010 and received oral RXB once daily for 5-13 days from the day after hemovac drain removal to postoperative day 14. Results: The primary study outcome was the prevalence of VTE, pulmonary embolism or death during follow up. The overall incidence of VTE was 1.69% (n=44); of these, 12 occurred in the RXB group and 32 in the nonprophylactic group. The odds ratio of VTE in the RXB group was 0.61. However, the statistical power of the study was 0.313 due to the low incidence of VTE. Conclusion: Treatment with oral chemical prophylaxis decreased the incidence of VTE after knee or hip arthroplasty in a Korean population. Furthermore, no serious complications occurred after administering oral RXB, which, coupled with its convenience, suggests oral RXB offers an attractive alternative to other agents. However, we recommend that further studies, including a multicenter study, be conducted to achieve adequate statistical power.
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참고문헌 (23)
참고문헌 신청
Leizorovicz A / 2005 / Epidemiology of venous thromboembolism in Asian patients undergoing major orthopedic surgery without thromboprophylaxis. The SMART study / J Thromb Haemost 3:28~34
Fujita S / 2000 / Deep venous thrombosis after total hip or total knee arthroplasty in patients in Japan / Clin Orthop Relat Res (375):168~174
Kim YH / 2002 / Incidence and natural history of deepvein thrombosis after total knee arthroplasty. A prospective, randomised study / J Bone Joint Surg Br 84:566~570
Leizorovicz A / 2007 / Epidemiology of post-operative venous thromboembolism in Asian patients. Results of the SMART venography study / Haematologica 92:1194~1200
Won MH / 2011 / Prevalence and risk factors of thromboembolism after joint arthroplasty without chemical thromboprophylaxis in an Asian population / J Arthroplasty 26:1106~1111
Fujita S / 2000 / Deep venous thrombosis after total hip or total knee arthroplasty in patients in Japan / Clin Orthop Relat Res (375):168~174
Kim YH / 2002 / Incidence and natural history of deepvein thrombosis after total knee arthroplasty. A prospective, randomised study / J Bone Joint Surg Br 84:566~570
Leizorovicz A / 2007 / Epidemiology of post-operative venous thromboembolism in Asian patients. Results of the SMART venography study / Haematologica 92:1194~1200
Won MH / 2011 / Prevalence and risk factors of thromboembolism after joint arthroplasty without chemical thromboprophylaxis in an Asian population / J Arthroplasty 26:1106~1111
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