지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 473 - 479 (7page)
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초록· 키워드
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Background and Purpose Many previous studies have investigated forward gait (FG), backward gait (BG), and dual-task gait (DG) in patients with Parkinson’s disease (PD). However, it remains uncertain whether gait parameters are implicated in motor symptoms or the risk of falling, especially in patients with de novo PD. Methods Demographic and clinical characteristics including the Fear of Falling Measure (FFM) were assessed in patients with de novo PD and in healthy subjects. A computerized gait analysis using the GAITRite system was performed for FG, BG, and DG. Te Unifed Parkinson’s Disease Rating Scale Part III was assessed in patients with PD. Results Tis prospective study included 24 patients with de novo PD and 27 controls. Compared with controls, patients with de novo PD showed a slower gait and shorter stride in all three gaits. Patients with de novo PD also exhibited increases in the stride-to-stride variability in the stride time and stride length of the gait for BG, increased length for DG, and no increase for FG. Moreover, the BG speed in de novo PD patients was signifcantly associated with their motor symptoms (bradykinesia, postural instability, gait difculty, and total motor score) and negatively correlated with the FFM score. Conclusions Te BG dynamics were more impaired and more closely related to motor symptoms and fear of falling than were the FG or DG dynamics in patients with de novo PD, indicating that BG parameters are potential biomarkers for the progression of PD.
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참고문헌 (30)
참고문헌 신청
Hausdorff JM / 2009 / Gait dynamics in Parkinson’s disease : common and distinct behavior among stride length, gait variability, and fractal-like scaling / Chaos 19:026113
Vieregge P / 1997 / Gait quantitation in Parkinson’s disease--locomotor disability and correlation to clinical rating scales / J Neural Transm(Vienna) 104:237~248
Morris ME / 1994 / The pathogenesis of gait hypokinesia in Parkinson’s disease / Brain 117:1169~1181
Hackney ME / 2009 / Backward walking in Parkinson’s disease / Mov Disord 24:218~223
Bryant MS / 2016 / Gait variability in Parkinson’s disease : levodopa and walking direction / Acta Neurol Scand 134:83~86
Vieregge P / 1997 / Gait quantitation in Parkinson’s disease--locomotor disability and correlation to clinical rating scales / J Neural Transm(Vienna) 104:237~248
Morris ME / 1994 / The pathogenesis of gait hypokinesia in Parkinson’s disease / Brain 117:1169~1181
Hackney ME / 2009 / Backward walking in Parkinson’s disease / Mov Disord 24:218~223
Bryant MS / 2016 / Gait variability in Parkinson’s disease : levodopa and walking direction / Acta Neurol Scand 134:83~86
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