지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Anorexia nervosa (AN) affects 2.9 million people, many of whom experience bone loss and increased fracture risk. In this article, we review data on the underlying pathophysiology of AN-related osteoporosis and possible approaches to disease management. Available research suggests that low body weight and decreased gonadal function are the strongest predictors of bone loss and fractures in patients with AN. Additionally, other metabolic disturbances have been linked to bone loss, including growth hormone resistance, low leptin concentrations, and hypercortisolemia, but those correlations are less consistent and lack evidence of causality. In terms of treatment of AN-related bone disease, weight gain has the most robust impact on bone mineral density (BMD). Restoration of gonadal function seems to augment this effect and may independently improve BMD. Bisphosphonates, insulin-like growth factor 1 supplementation, and teriparatide may also be reasonable considerations, however need long-term efficacy and safety data.
목차
등록된 정보가 없습니다.
참고문헌 (84)
참고문헌 신청
GBD 2015 Disease and Injury Incidence and Prevalence Collaborators / 2016 / Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015 / Lancet 388:1545~1602
Hoek HW / 2006 / Incidence, prevalence and mortality of anorexia nervosa and other eating disorders / Curr Opin Psychiatry 19:389~394
Lucas AR / 1999 / Long-term fracture risk among women with anorexia nervosa: a population-based cohort study / Mayo Clin Proc 74:972~977
Schorr M / 2017 / Bone density, body composition, and psychopathology of anorexia nervosa spectrum disorders in DSM-IV vs DSM-5 / Int J Eat Disord 50:343~351
Grinspoon S / 2000 / Prevalence and predictive factors for regional osteopenia in women with anorexia nervosa / Ann Intern Med 133:790~794
Hoek HW / 2006 / Incidence, prevalence and mortality of anorexia nervosa and other eating disorders / Curr Opin Psychiatry 19:389~394
Lucas AR / 1999 / Long-term fracture risk among women with anorexia nervosa: a population-based cohort study / Mayo Clin Proc 74:972~977
Schorr M / 2017 / Bone density, body composition, and psychopathology of anorexia nervosa spectrum disorders in DSM-IV vs DSM-5 / Int J Eat Disord 50:343~351
Grinspoon S / 2000 / Prevalence and predictive factors for regional osteopenia in women with anorexia nervosa / Ann Intern Med 133:790~794
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