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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 영남대학교 의과대학 Journal of Yeungnam Medical Science Yeungnam University Journal of Medicine 제36권 제2호
- 발행연도
- 2019.1
- 수록면
- 124 - 135 (12page)
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초록· 키워드
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Background: We aimed to establish robust histoprognostic predictors on residual rectal cancer after preoperative chemoradiotherapy (CRT). Methods: Analyzing known histoprognostic factors in 146 patients with residual disease allows associations with patient outcome to be evaluated. Results: The median follow-up time was 77.8 months, during which 59 patients (40.4%) experienced recurrence and 41 (28.1%) died of rectal cancer. On univariate analysis, residual tumor size, ypT category, ypN category, ypTNM stage, downstage, tumor regression grade, lymphatic invasion, perineural invasion, venous invasion, and circumferential resection margin (CRM) were significantly associated with recurrence free survival (RFS) or/and cancer-specific survival (CSS) (all p<0.005). On multivariate analysis, higher ypTNM stage and CRM positivity were identified as independent prognostic factors for RFS (ypTNM stage, p=0.024; CRM positivity, p<0.001) and CSS (p=0.022, p=0.017, respectively). Furthermore, CRM positivity was an independent predictor of reduced RFS and CSS, irrespective of subgrouping according to downstage (non-downstage, p<0.001 and p<0.001; downstage, p=0.002 and p=0.002) or lymph node metastasis (non-metastasis, p<0.001 and p=0.001; metastasis, p<0.001 and p<0.001). Conclusion: CRM status may be as powerful as ypTNM stage as a prognostic indicator for patient outcome in patients with residual rectal cancer after preoperative CRT.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Sannier A / 2014 / Pathological prognostic factors in locally advanced rectal carcinoma after neoadjuvant radiochemotherapy: analysis of 113 cases / Histopathology 65:623~630
Quah HM / 2008 / Pathologic stage is most prognostic of disease-free survival in locally advanced rectal cancer patients after preoperative chemoradiation / Cancer 113:57~64
Rödel C / 2005 / Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer / J Clin Oncol 23:8688~8696
Medich D / 2001 / Preoperative chemoradiotherapy and radical surgery for locally advanced distal rectal adenocarcinoma: pathologic findings and clinical implications / Dis Colon Rectum 44:1123~1128
Guillem JG / 2005 / Long-term oncologic outcome following preoperative combined modality therapy and total mesorectal excision of locally advanced rectal cancer / Ann Surg 241:829~836
Quah HM / 2008 / Pathologic stage is most prognostic of disease-free survival in locally advanced rectal cancer patients after preoperative chemoradiation / Cancer 113:57~64
Rödel C / 2005 / Prognostic significance of tumor regression after preoperative chemoradiotherapy for rectal cancer / J Clin Oncol 23:8688~8696
Medich D / 2001 / Preoperative chemoradiotherapy and radical surgery for locally advanced distal rectal adenocarcinoma: pathologic findings and clinical implications / Dis Colon Rectum 44:1123~1128
Guillem JG / 2005 / Long-term oncologic outcome following preoperative combined modality therapy and total mesorectal excision of locally advanced rectal cancer / Ann Surg 241:829~836
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