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논문 기본 정보

자료유형
학술저널
저자정보
Jeongun Choe (Yonsei University) Jiyun Park (Yonsei University) Jihye Lee (Yonsei University) Jong-Souk Yeo (Yonsei University)
저널정보
한국진공학회(ASCT) Applied Science and Convergence Technology Applied Science and Convergence Technology Vol.24 No.5
발행연도
2015.9
수록면
196 - 202 (7page)

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초록· 키워드

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Human blood consists of 55% of plasma and 45% of blood cells such as white blood cell (WBC) and red blood cell (RBC). In plasma, there are many kinds of promising biomarkers, which can be used for the diagnosis of various diseases and biological analysis. For diagnostic tools such as a lab-on-a-chip (LOC), blood plasma separation is a fundamental step for accomplishing a high performance in the detection of a disease. Highly efficient separators can increase the sensitivity and selectivity of biosensors and reduce diagnostic time. In order to achieve a higher yield in blood plasma separation, we propose a novel fluid wing structure that is optimized by COMSOL simulations by varying the fluidic channel width and the angle of the bifurcation. The fluid wing structure is inspired by the inertial particle separator system in helicopters where sand particles are prevented from following the air flow to an engine. The structure is ameliorated in order to satisfy biological and fluidic requirements at the micro scale to achieve high plasma yield and separation efficiency. In this study, we fabricated the fluid wing structure for the efficient microfluidic blood plasma separation. The high plasma yield of 67% is achieved with a channel width of 20 μm in the fabricated fluidic chip and the result was not affected by the angle of the bifurcation.

목차

I. Introduction
II. Experiment
III. Results and Discussion
IV. Conclusions
References

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