메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한신경정신의학회 PSYCHIATRY INVESTIGATION PSYCHIATRY INVESTIGATION 제11권 제4호
발행연도
2014.1
수록면
345 - 362 (18page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
People called night owls habitually have late bedtimes and late times of arising, sometimes suffering a heritable circadian disturbance called delayed sleep phase syndrome (DSPS). Those with DSPS, those with more severe progressively-late non-24-hour sleep-wake cycles, and those with bipolar disorder may share genetic tendencies for slowed or delayed circadian cycles. We searched for polymorphisms associated with DSPS in a case-control study of DSPS research participants and a separate study of Sleep Center patients undergoing polysomnography. In 45 participants, we resequenced portions of 15 circadian genes to identify unknown polymorphisms that might be associated with DSPS, non-24-hour rhythms, or bipolar comorbidities. We then genotyped single nucleotide polymorphisms (SNPs) in both larger samples, using Illumina Golden Gate assays. Associations of SNPs with the DSPS phenotype and with the morningness-eveningness parametric phenotype were computed for both samples, then combined for meta-analyses. Delayed sleep and “eveningness” were inversely associated with loci in circadian genes NFIL3 (rs2482705) and RORC (rs3828057). A group of haplotypes overlapping BHLHE40 was associated with non-24-hour sleep-wake cycles, and less robustly, with delayed sleep and bipolar disorder (e.g., rs34883305, rs34870629, rs74439275, and rs3750275 were associated with n=37, p=4.58E-09, Bonferroni p=2.95E-06). Bright light and melatonin can palliate circadian disorders, and genetics may clarify the underlying circadian photoperiodic mechanisms. After further replication and identification of the causal polymorphisms, these findings may point to future treatments for DSPS, non-24-hour rhythms, and possibly bipolar disorder or depression.
#Delayed sleep phase syndrome #Non-24 hour sleep-wake disorder #Bipolar disorder #BHLHE40 #NFIL3 #RORC

목차

등록된 정보가 없습니다.

참고문헌 (1)

참고문헌 신청
Gale C / 1998 / Larks and owls and health, wealth, and wisdom / BMJ 317 : 1675 ~ 1677 | 2. [학술지(정기간행물)] - Roberts RD / 1999 / Morningness-eveningness and intelligence: early to bed, early to rise will likely make you anything but wise! / Pers Individ Dif 27 : 1123 ~ 1133 | 3. [학술지(정기간행물)] - Merikanto I / 2013 / Evening types are prone to depression / Chronobiol Int 30 : 719 ~ 725 | 4. [학술지(정기간행물)] - Lee HJ / 2011 / Delayed sleep phase syndrome is related to seasonal affective disorder / J Affect Disord 133 : 573 ~ 579 | 5. [학술지(정기간행물)] - Giglio LM / 2010 / Circadian preference in bipolar disorder / Sleep Breath 14 : 153 ~ 155 | 6. [학술지(정기간행물)] - Robillard R / 2013 / Delayed sleep phase in young people with unipolar or bipolar affective disorders / J Affect Disord 145 : 260 ~ 263 | 7. [학술지(정기간행물)] - Lewy AJ / 2009 / Circadian misalignment in mood disturbances / Curr Psychiatry Rep 11 : 459 ~ 465 | 8. [학술지(정기간행물)] - Murray CJ / 2012 / Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010 / Lancet 380 : 2197 ~ 2223 | 9. [학술지(정기간행물)] - Saxvig IW / 2012 / Prevalence and correlates of delayed sleep phase in high school students / Sleep Med 13 : 193 ~ 199 | 10. [학술지(정기간행물)] - Randler C / 2011 / Association between morningness-eveningness and mental and physical health in adolescents / Psychol Health Med 16 : 29 ~ 38 | 11. [학술지(정기간행물)] - Tzischinsky O / 2011 / Eveningness, sleep patterns, daytime functioning, and quality of life in Israeli adolescents / Chronobiol Int 28 : 338 ~ 343 | 12. [학술지(정기간행물)] - O’Brien EM / 2005 / Sleep and risk-taking behavior in adolescents / Behav Sleep Med 3 : 113 ~ 133 | 13. [학술지(정기간행물)] - Reid KJ / 2012 / Systematic evaluation of Axis-I DSM diagnoses in delayed sleep phase disorder and evening-type circadian preference / Sleep Med 13 : 1171 ~ 1177 | 14. [단행본] - Winkelman J / 2006 / The International Classification of Sleep Disorders, Second Edition, Pocket Version: Diagnostic and Coding Manual / American Academy of Sleep Disorders | 15. [학술지(정기간행물)] - Kripke DF / 2011 / Mortality related to actigraphic long and short sleep / Sleep Med 12 : 28 ~ 33 | 16. [학술지(정기간행물)] - Brown FM / 1993 / Psychometric equivalence of an improved Basic Language Morningness (BALM) scale using industrial population within comparisons / Ergonomics 36 : 191 ~ 197 | 17. [학술지(정기간행물)] - Koskenvuo M / 2007 / Heritability of diurnal type: a nationwide study of 8753 adult twin pairs / J Sleep Res 16 : 156 ~ 162 | 18. [학술지(정기간행물)] - Barclay NL / 2010 / Diurnal preference and sleep quality: same genes? A study of young adult twins / Chronobiol Int 27 : 278 ~ 296 | 19. [학술지(정기간행물)] - Vink JM / 2001 / Genetic analysis of morningness and eveningness / Chronobiol Int 18 : 809 ~ 822 | 20. [학술지(정기간행물)] - Randler C / 2008 / Morningness-eveningness comparison in adolescents from different countries around the world / Chronobiol Int 25 : 1017 ~ 1028 | 21. [학술지(정기간행물)] - Barclay NL / 2013 / Monozygotic twin differences in non-shared environmental factors associated with chronotype / J Biol Rhythms 28 : 51 ~ 61 | 22. [학술지(정기간행물)] - Brown SA / 2008 / Molecular insights into human daily behavior / Proc Natl Acad Sci U S A 105 : 1602 ~ 1607 | 23. [학술지(정기간행물)] - Micic G / 2013 / The endogenous circadian temperature period length (tau) in delayed sleep phase disorder compared to good sleepers / J Sleep Res 22 : 617 ~ 624 | 24. [학술지(정기간행물)] - McCarthy MJ / 2013 / Genetic and clinical factors predict lithium’s effects on PER2 gene expression rhythms in cells from bipolar disorder patients / Transl Psychiatry 3 : e318 ~ | 25. [학술지(정기간행물)] - Katzenberg D / 1998 / A clock polymorphism associated with human diurnal preference / Sleep 21 : 569 ~ 576 | 26. [학술지(정기간행물)] - Ebisawa T / 2013 / Analysis of the molecular pathophysiology of sleep disorders relevant to a disturbed biological clock / Mol Genet Genomics 288 : 185 ~ 193 | 27. [학위논문] - Cade BE / 2010 / Variation and Selection in Human Circadian Clock Genes / 박사 / University of Surrey | 28. [학술지(정기간행물)] - Lim AS / 2012 / A common polymorphism near PER1 and the timing of human behavioral rhythms / Ann Neurol 72 : 324 ~ 334 | 29. [학술지(정기간행물)] - Jones CR / 2013 / Genetic basis of human circadian rhythm disorders / Exp Neurol 243 : 28 ~ 33 | 30. [학술지(정기간행물)] - Kripke DF / 2008 / Delayed sleep phase cases and controls / J Circadian Rhythms 6 : 6 ~ | 31. [학술지(정기간행물)] - Daniel F. Kripke / 2010 / Genotyping Sleep Disorders Patients / PSYCHIATRY INVESTIGATION 7 (1) : 36 ~ 42 | 32. [학술지(정기간행물)] - Kripke DF / 2011 / Polymorphisms in melatonin synthesis pathways: possible influences on depression / J Circadian Rhythms 9 : 8 ~ | 33. [학술지(정기간행물)] - 이민규 / 2012 / Evaluation of Two Circadian Rhythm Questionnaires for Screening for the Delayed Sleep Phase Disorder / PSYCHIATRY INVESTIGATION 9 (3) : 236 ~ 244 | 34. [학술지(정기간행물)] - Kripke DF / 2013 / FMR1, circadian genes and depression: suggestive associations or false discovery? / J Circadian Rhythms 11 : 3 ~ | 35. [학술지(정기간행물)] - Horne JA / 1976 / A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms / Int J Chronobiol 4 : 97 ~ 110 | 36. [단행본] - Terman M / 2008 / Morningness-Eveningness Questionnaire (Revised) / New York State Psychiatric Institute | 37. [학술지(정기간행물)] - Hirschfeld RM / 2003 / Validity of the Mood Disorder Questionnaire: a general population study / Am J Psychiatry 160 : 178 ~ 180 | 38. [학술지(정기간행물)] - Rush AJ / 2003 / The 16-item Quick Inventory of Depressive Symptomatology (QIDS), clinical rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression / Biol Psychiatry 54 : 573 ~ 583 | 39. [학술지(정기간행물)] - Ando K / 2002 / Delayed and advanced sleep phase symptoms / Isr J Psychiatry Relat Sci 39 : 11 ~ 18 | 40. [인터넷자원] - Kripke DF / / EF015893-EF015905 and EF028070. GenBank Nucleotide | 41. [학술지(정기간행물)] - Gottlieb DJ / 2007 / Genome-wide association of sleep and circadian phenotypes / BMC Med Genet 8 (Suppl 1) : S9 ~ | 42. [학술지(정기간행물)] - Nievergelt CM / 2013 / Inference of human continental origin and admixture proportions using a highly discriminative ancestry informative 41-SNP panel / Investig Genet 4 : 13 ~ | 43. [학술지(정기간행물)] - Purcell S / 2007 / PLINK: a tool set for whole-genome association and populationbased linkage analyses / Am J Hum Genet 81 : 559 ~ 575 | 44. [학술지(정기간행물)] - Storey JD / 2003 / Statistical significance for genomewide studies / Proc Natl Acad Sci U S A 100 : 9440 ~ 9445 | 45. [학술지(정기간행물)] - Honma S / 2002 / Dec1 and Dec2 are regulators of the mammalian molecular clock / Nature 419 : 841 ~ 844 | 46. [학술지(정기간행물)] - Barrett JC / 2005 / Haploview: analysis and visualization of LD and haplotype maps / Bioinformatics 21 : 263 ~ 265 | 47. [학술지(정기간행물)] - Kripke DF / 1978 / Circadian rhythm disorders in manic-depressives / Biol Psychiatry 13 : 335 ~ 351 | 48. [학술지(정기간행물)] - Johnson AD / 2008 / SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap / Bioinformatics 24 : 2938 ~ 2939 | 49. [인터넷자원] - Torkamani A / / Scripps Genome Adviser: Annotation and Distributed Variant Interpretation Server | 50. [학술지(정기간행물)] - Roecklein KA / 2012 / Melanopsin gene variations interact with season to predict sleep onset and chronotype / Chronobiol Int 29 : 1036 ~ 1047 | 51. [학술지(정기간행물)] - Ioannidis JP / 2005 / Why most published research findings are false / PLoS Med 2 : e124 ~ | 52. [학술지(정기간행물)] - Ebisawa T / 2001 / Association of structural polymorphisms in the human period3gene with delayed sleep phase syndrome / EMBO Rep 2 : 342 ~ 346 | 53. [학술지(정기간행물)] - Archer SN / 2003 / A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference / Sleep 26 : 413 ~ 415 | 54. [학술지(정기간행물)] - Carpen JD / 2005 / A single-nucleotide polymorphism in the 5’-untranslated region of the hPER2 gene is associated with diurnal preference / J Sleep Res 14 : 293 ~ 297 | 55. [학술지(정기간행물)] - Lee HJ / 2007 / Allelic variants interaction of CLOCK gene and G-protein beta3 subunit gene with diurnal preference / Chronobiol Int 24 : 589 ~ 597 | 56. [학술지(정기간행물)] - Minami Y / 2013 / Mammalian circadian clock: the roles of transcriptional repression and delay / Handb Exp Pharmacol 217 : 359 ~ 377 | 57. [학술지(정기간행물)] - Zhang EE / 2009 / A genome-wide RNAi screen for modifiers of the circadian clock in human cells / Cell 139 : 199 ~ 210 | 58. [학술지(정기간행물)] - Albrecht U / 2012 / Timing to perfection: the biology of central and peripheral circadian clocks / Neuron 74 : 246 ~ 260 | 59. [학술지(정기간행물)] - Pagani L / 2010 / The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts / PLoS ONE 5 : e13376 ~ | 60. [학술지(정기간행물)] - Ebisawa T / 2009 / Self-sustained circadian rhythm in cultured human mononuclear cells isolated from peripheral blood / Neurosci Res 66 : 223 ~ 227 | 61. [학술지(정기간행물)] - Nakashima A / 2008 / DEC1 modulates the circadian phase of clock gene expression / Mol Cell Biol 28 : 4080 ~ 4092 | 62. [학술지(정기간행물)] - Shi J / 2008 / Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm / Am J Med Genet B Neuropsychiatr Genet 147B : 1047 ~ 1055 | 63. [학술대회논문] - Halberg F / 1967 / Physiologic Considerations Underlying Rhythmometry, with Special Reference to Emotional Illness / Symposium on Biological Cycles and Psychiatry. Symposium Bell-Air III : 73 ~ 126 | 64. [학술지(정기간행물)] - Bamne MN / 2013 / Application of an ex vivo cellular model of circadian variation for bipolar disorder research: a proof of concept study / Bipolar Disord 15 : 694 ~ 700 | 65. [학술지(정기간행물)] - Kripke DF / 2009 / Circadian polymorphisms associated with affective disorders / J Circadian Rhythms 7 : 2 ~ | 66. [학술지(정기간행물)] - McCarthy MJ / 2011 / Functional genetic variation in the Rev-Erbalpha pathway and lithium response in the treatment of bipolar disorder / Genes Brain Behav 10 : 852 ~ 861 | 67. [학술지(정기간행물)] - Vitaterna MH / 1994 / Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior / Science 264 : 719 ~ 725 | 68. [학술지(정기간행물)] - Roybal K / 2007 / Mania-like behavior induced by disruption of CLOCK / Proc Natl Acad Sci U S A 104 : 6404 ~ 6411 | 69. [학술지(정기간행물)] - Etain B / 2012 / Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder / Hum Mol Genet 21 : 4030 ~ 4037 | 70. [학술지(정기간행물)] - Li JZ / 2013 / Circadian patterns of gene expression in the human brain and disruption in major depressive disorder / Proc Natl Acad Sci U S A 110 : 9950 ~ 9955 | 71. [학술지(정기간행물)] - Sekula LK / 1997 / Neuroendocrine aspects of primary endogenous depression XV: mathematical modeling of nocturnal melatonin secretion in major depressives and normal controls / Psychiatry Res 69 : 143 ~ 153 | 72. [학술지(정기간행물)] - Nurnberger JI Jr / 2000 / Melatonin suppression by light in euthymic bipolar and unipolar patients / Arch Gen Psychiatry 57 : 572 ~ 579 | 73. [학술지(정기간행물)] - Tuunainen A / 2002 / Depression and endogenous melatonin in postmenopausal women / J Affect Disord 69 : 149 ~ 158 | 74. [학술지(정기간행물)] - Emens J / 2009 / Circadian misalignment in major depressive disorder / Psychiatry Res 168 : 259 ~ 261 | 75. [학술지(정기간행물)] - Meliska CJ / 2011 / Relationship of morningness-eveningness questionnaire score to melatonin and sleep timing, body mass index and atypical depressive symptoms in peri- and post-menopausal women / Psychiatry Res 188 : 88 ~ 95 | 76. [학술지(정기간행물)] - Naito E / 2008 / Reorganization of the suprachiasmatic nucleus coding for day length / J Biol Rhythms 23 : 140 ~ 149 | 77. [학술지(정기간행물)] - Honma S / 2012 / Suprachiasmatic nucleus: cellular clocks and networks / Prog Brain Res 199 : 129 ~ 141 | 78. [단행본] - Wirz-Justice A / 2013 / Chronotherapeutics for Affective Disorders: A Clinician’s Manual for Light and Wake Therapy. 2nd Edition / Karger | 79. [학술지(정기간행물)] - Schlager DS / 1994 / Early-morning administration of short-acting beta blockers for treatment of winter depression / Am J Psychiatry 151 : 1383 ~ 1385 | 80. [학술지(정기간행물)] - Dardente H / 2010 / A molecular switch for photoperiod responsiveness in mammals / Curr Biol 20 : 2193 ~ 2198 | 81. [학술지(정기간행물)] - Hazlerigg D / 2012 / The evolutionary physiology of photoperiodism in vertebrates / Prog Brain Res 199 : 413 ~ 422 | 82. [학술지(정기간행물)] - Masumoto KH / 2010 / Acute induction of Eya3 by late-night light stimulation triggers TSHβ expression in photoperiodism / Curr Biol 20 : 2199 ~ 2206 | 83. [학술지(정기간행물)] - Prendergast BJ / 2013 / Rapid induction of hypothalamic iodothyronine deiodinase expression by photoperiod and melatonin in juvenile Siberian hamsters (Phodopus sungorus) / Endocrinology 154 : 831 ~ 841 | 84. [학술지(정기간행물)] - Stevenson TJ / 2013 / Reversible DNA methylation regulates seasonal photoperiodic time measurement / Proc Natl Acad Sci U S A 110 : 16651 ~ 16656 | 85. [학술지(정기간행물)] - Henson JR / 2013 / Exogenous T3 elicits long day-like alterations in testis size and the RFamides Kisspeptin and gonadotropin-inhibitory hormone in short-day Siberian hamsters / J Biol Rhythms 28 : 193 ~ 200 | 86. [학술지(정기간행물)] - Hampp G / 2008 / Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood / Curr Biol 18 : 678 ~ 683 | 87. [학술지(정기간행물)] - Leproult R / 2001 / Transition from dim to bright light in the morning induces an immediate elevation of cortisol levels / J Clin Endocrinol Metab 86 : 151 ~ 157 | 88. [학술지(정기간행물)] - Scheer FAJL / 1999 / Light affects morning salivary cortisol in humans / J Clin Endocrinol Metab 84 : 3395 ~ 3398 | 89. [학술지(정기간행물)] - Lamia KA / 2011 / Cryptochromes mediate rhythmic repression of the glucocorticoid receptor / Nature 480 : 552 ~ 556 | 90. [학술지(정기간행물)] - Wilhelmsen-Langeland A / 2013 / A randomized controlled trial with bright light and melatonin for the treatment of delayed sleep phase disorder: effects on subjective and objective sleepiness and cognitive function / J Biol Rhythms 28 : 306 ~ 321 google schola

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0