지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 24 - 28 (5page)
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초록· 키워드
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Background/Aims: Inflammatory bowel disease (IBD) is a chronic disease of the gastrointestinal tract, whose etiologies are still unknown. This study was performed to evaluate the humoral immune response in terms of B cell functions in selected IBD patients.
Methods: Eighteen pediatric patients with IBD, including 12 cases of ulcerative colitis (UC) and six with Crohn disease (CD), were enrolled in this study. The pneumococcal vaccine was injected in all patients, and the IgG antibody level to the polysaccharide antigen was measured before and 4 weeks after injection. The B cell switch-recombination process was evaluated.
Results: Five patients with IBD (three CD and two UC) had defects in B cell switching, which was significantly higher than in controls (p=0.05). Ten patients had a specific antibody deficiency and exhibited a higher frequency of bacterial infection than the healthy group. The mean increased level of IgG after vaccination was lower in IBD patients (82.9±32.5 μg/mL vs 219.8±59.0 μg/mL; p=0.001). Among the patients who had an insufficient response, no significant difference in the number of switched memory B-cell was observed.
Conclusions: A defect in B lymphocyte switching was observed in pediatric IBD patients, and especially in those patients with CD. Owing to an increased risk of bacterial infections in those patients with antibody production defects, pneumococcal vaccination could be recommended. However, not all patients can benefit from the vaccination, and several may require other prophylactic methods.
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참고문헌 (26)
참고문헌 신청
Aberra FN / 2005 / Methods to avoid infections in patients with inflammatory bowel disease / Inflamm Bowel Dis 11:685~695
Viget N / 2008 / Opportunistic infections in patients with inflammatory bowel disease: prevention and diagnosis / Gut 5:549~558
Cucino C / 2001 / The comorbid occurrence of other diagnoses in patients with ulcerative colitis and Crohn’s disease / Am J Gastroenterol 96:2107~2112
Melmed GY / 2009 / Vaccination strategies for patients with inflammatory bowel disease on immunomodulators and biologics / Inflamm Bowel Dis 15:1410~1416
Sands BE / 2004 / Guidelines for immunizations in patients with inflammatory bowel disease / Inflamm Bowel Dis 10:677~692
Viget N / 2008 / Opportunistic infections in patients with inflammatory bowel disease: prevention and diagnosis / Gut 5:549~558
Cucino C / 2001 / The comorbid occurrence of other diagnoses in patients with ulcerative colitis and Crohn’s disease / Am J Gastroenterol 96:2107~2112
Melmed GY / 2009 / Vaccination strategies for patients with inflammatory bowel disease on immunomodulators and biologics / Inflamm Bowel Dis 15:1410~1416
Sands BE / 2004 / Guidelines for immunizations in patients with inflammatory bowel disease / Inflamm Bowel Dis 10:677~692
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