지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background: Luliconazole (LLCZ) is an imidazole antifungal agent widely used in Japan for treatment of tinea, cutaneous candidiasis, and pityriaisis versicolor, etc. Theoretically, its potent antifungal activity should make it a viable option for various conditions of dermatophytoses, but there has been no studies to support the notion thus far.
Objective: This prompted the authors to investigate the distribution of minimum inhibitory concentration (MIC) of luliconazole by carrying out in vitro antifungal susceptibility test on Trichophyton (T.) species clinically isolated from Korean subjects with tinea pedis.
Methods: In vitro antifungal susceptibility test, with broth macrodilution method of luliconazole and terbinafine hydrochloride (TBF) as reference drug on two clinically isolated Trichophton species (22strains of T. rubrum, 5 of T. mentagrophytes), was carried out.
Results: The range of MIC for LLCZ on the total of 27 strains was 0.0110~0.0140 μg/mL (geometric mean: 0.0027 μg/mL), and the range for TBF was 0.0120~0.0250 μg/mL (geometric mean: 0.0042μg/mL). Additionally, the geometric mean for MIC of LLCZ on T. mentagrophytes was 0.0125 μg/mL,and on T. rubrum, it was 0.0019 μg/mL. No strain showed resistance in vitro.
Conclusions: The authors hence demonstrated that antifungal activity of LLCZ in vitro against Trichophyton species clinically isolated from Korean subjects is quite superior. These findings emphasize the usefulness of LLCZ, a promising new imidazole, for the topical management of dermatophytoses.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Barros ME / 2005 / Determination of susceptibility/resistance to antifungal drugs of Trichophyton mentagrophytes isolates by a macrodilution method / Can J Microbiol 51 : 98
Espinel-Ingroff A / 1991 / Shadomy S. Comparison study of broth macrodilution and microdilution antifungal susceptibility tests / J Clin Microbiol 29 : 1089 ~ 1094
Evans EG / 1994 / comparison of terbinafine (Lamisil) 1% cream given for one week with clotrimazole (Canesten) 1% cream given for four weeks, in the treatment of tinea pedis
Georgopapadakou NH / 1994 / Human mycoses: drugs and targets for emerging pathogens / Science : 371 ~ 373
Gupta AK / 2001 / Ciclopirox: an overview / Int J Dermatol 40 : 305 ~ 310
Espinel-Ingroff A / 1991 / Shadomy S. Comparison study of broth macrodilution and microdilution antifungal susceptibility tests / J Clin Microbiol 29 : 1089 ~ 1094
Evans EG / 1994 / comparison of terbinafine (Lamisil) 1% cream given for one week with clotrimazole (Canesten) 1% cream given for four weeks, in the treatment of tinea pedis
Georgopapadakou NH / 1994 / Human mycoses: drugs and targets for emerging pathogens / Science : 371 ~ 373
Gupta AK / 2001 / Ciclopirox: an overview / Int J Dermatol 40 : 305 ~ 310
이 논문의 저자 정보
최근 본 자료
댓글(0)
0