지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background: Seborrheic dermatitis is chronic relapsing inflammatory skin disorder. Bokbunja (Rubus coreanus Miquel) is a wild berry to Rosaceae genus and also known to have an anti-inflammation effect.
Objective: We were to determine the effect of Rubus coreanus Miquel extract for seborrheic dermatitis in vivo and in vitro.
Methods: Seven patients with mild seborrheic dermatitis were enrolled in this study. PCR and culture were performed to identify subtypes of six Malassezia species (M. restricta, M. globosa, M. furfur, M.
slooffiae, M. sympodialis, M. obtusa). Topical application of Rubus coreanus Miquel Extract was applied twice daily for 2 weeks. Clinical improvement and safety assessment were performed initially and 2weeks later. Minimum inhibitory concentration (MIC) was evaluated on Malassezia globosa comparing with ketoconazole and itraconazole. Sebum production was also checked prior the experiment and 2weeks later.
Results: Five of seven patients showed improvement. No significant adverse effects were found during the clinical trial. Mild dryness was reported in 2 patients but they resolved spontaneously without any treatment. Rubus coreanus Miquel Extract didn't show antimicrobial effect to Malassezia globosa.
However, Rubus coreanus Miquel Extract showed anti-inflammatory effect.
Conclusion: In this study, we were verified that Rubus coreanus Miquel Extract can be applied for seborrheic dermatitis treatment. And this action mechanism is not related with antimicrobial effect.
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참고문헌 (16)
참고문헌 신청
Bae GH / / The medicinal plants of Korea / Kyohak Publishing Co : 231 ~
Elewski BE / 2009 / Safe and effective treatment of seborrheic dermatitis / Cutis 83 : 333 ~ 338
Kim KH / 2000 / Antioxidative activity of tannins from Rubus coreanum / Yakhak Hoeji 44 : 354 ~ 357
Kim SJ / 1992 / Clinical effect of topical ketoconazole in seborrheic dermatitis of scalp / Korean J Dermatol 30 : 625 ~ 632
Korean dermatological association textbook editing board / 2008 / Dermatology. 5th edition / Ryo Moon Gak : 185 ~ 187
Elewski BE / 2009 / Safe and effective treatment of seborrheic dermatitis / Cutis 83 : 333 ~ 338
Kim KH / 2000 / Antioxidative activity of tannins from Rubus coreanum / Yakhak Hoeji 44 : 354 ~ 357
Kim SJ / 1992 / Clinical effect of topical ketoconazole in seborrheic dermatitis of scalp / Korean J Dermatol 30 : 625 ~ 632
Korean dermatological association textbook editing board / 2008 / Dermatology. 5th edition / Ryo Moon Gak : 185 ~ 187
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