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- Earlier we have described new water-soluble Ag-and Zn-derivatives of tetrachloridemeso-tetra(4-N-oxiethylpyridyl) porphyrin(TOEtPyP) as potential anticancer drugs. In this workthe effect of one of these metal porphyrins, TOEtPyP Ag, on the cell population kinetics was stu-died in vitrousing morphological and biochemical techniques. The results suggested thatTOEtPyP Ag action consisted in the simultaneous suppression of the cell growth and activation ofthe cell death. About 40% of the cells were shown to die via apoptotic pathway. So, the porphyrinstudied may be attributed to inducers of both necrotic and apoptotic processes. The results ob-tained support our previous assertion that TOEtPyP Ag may be considered as a potential che-motherapeutic agent.
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참고문헌 (27)
참고문헌 신청
Aderem A / 1999 / Mechanisms of phagocytosis in macrophages / Annu. Rev. Immunol 17 : 593 ~ 623
Al-Mutairi DA / 2006 / Photosensitizing action of isomeric Zn N-methylpyridyl porphyrins in human carcinoma cells / Free Radical Res 40 (5) : 477 ~ 483
Berg K / 2005 / Porphyrin-related photosensitizers for cancer imaging and therapeutic applications / J. Microsc 218 (2) : 133 ~ 147
Cohen GM / 1992 / Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation / Biochemical J 286 : 331 ~ 334
Darzynkiewicz Z. / 1990 / Differential staining of DNA and RNA in intact cells and isolated cell nuclei with acridine orange / Methods Cell Biol 33 : 285 ~ 298
Al-Mutairi DA / 2006 / Photosensitizing action of isomeric Zn N-methylpyridyl porphyrins in human carcinoma cells / Free Radical Res 40 (5) : 477 ~ 483
Berg K / 2005 / Porphyrin-related photosensitizers for cancer imaging and therapeutic applications / J. Microsc 218 (2) : 133 ~ 147
Cohen GM / 1992 / Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation / Biochemical J 286 : 331 ~ 334
Darzynkiewicz Z. / 1990 / Differential staining of DNA and RNA in intact cells and isolated cell nuclei with acridine orange / Methods Cell Biol 33 : 285 ~ 298
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