지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Ixeris dentata is a typical oriental herb. It is a widely distributed perennial
in Korea, Japan and China, which belongs to the Compositae Family. The whole plant
of I. dentata has been used for the treatment of pneumonia, contusion, tumor and
hepatitis. It has also been used for the treatment of allergic diseases as a folk therapy
in Korea. I. dentata is known to have aliphatics, triterpenoids and sesquiterpene
glycosides in its composition. The present study was designed to explore the protective
effects of water- and ethanol-extracts from I. dentata on irradiated rodents. For oral
administration (twice per day), the extractive powder of I. dentata and the positive
control (ascorbic acid) were dissolved at a concentration of 0.5 and 250 mg ml-1 in
saline, respectively. Thirty days after irradiation, the ratio of the weight of the testis to
the body weight was lower than 50% in the radiation groups than the control group.
The ALP concentrations in the group treated with the water-extracts of the leaf were
79.68±1.39% (p⁄0.05) of those of the radiation control. Both of the SGOT and SGPT in
the group treated with the ethanol-extract of the root were 72.68±0.95 and 77.87±5.74
(p⁄0.05) of those of the radiation control, respectively. The levels of DNA damage
induced by gamma radiation decreased in the experimental group to which the
extracts of I. dentata were administered before irradiation. In conclusion, these results
indicate that the extracts of I. dentata have an excellent ability to reduce the radicals
and they have a protective effect on DNA breakage caused by radiation.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Bowden RD / 2003. / Tail profilea moreaccurate system for analyzing DNA damage using theComet assay. 537 : 1 ~ 9
Bramer I / 2004. / Induction and repair of radiation-inducedDNA double-strand breaks in human fibroblasts are notaffected by terminal differentiation. DNA Repair. 3 3 : 113 ~
Chung HS / / MJ Kim and HM Kim. 2002. Nitricoxide and tumor necrosis factor-α production by Ixerisdentata in mouse peritoneal macrophages. J. Ethnopharmacology.82 82 : 217 ~
El-Demerdash / 2001. / Effects of selenium and mercuryon the enzymatic activities and lipid peroxidation inbrain and blood of rats. J. Environ. Sci. HealthB. 36 36: : 489 ~ 4
Fukuda S / 2004 / Age-relatedchanges in blood pressure concentrationsof serum biochemical constituents and weightsof organs in the SHR/Izm 53 : 67 ~ 72
Bramer I / 2004. / Induction and repair of radiation-inducedDNA double-strand breaks in human fibroblasts are notaffected by terminal differentiation. DNA Repair. 3 3 : 113 ~
Chung HS / / MJ Kim and HM Kim. 2002. Nitricoxide and tumor necrosis factor-α production by Ixerisdentata in mouse peritoneal macrophages. J. Ethnopharmacology.82 82 : 217 ~
El-Demerdash / 2001. / Effects of selenium and mercuryon the enzymatic activities and lipid peroxidation inbrain and blood of rats. J. Environ. Sci. HealthB. 36 36: : 489 ~ 4
Fukuda S / 2004 / Age-relatedchanges in blood pressure concentrationsof serum biochemical constituents and weightsof organs in the SHR/Izm 53 : 67 ~ 72
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