지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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In this study we present a mammalian cell culture model that allows to study the effect of endocrine disruptors (EDCs) on aromatase activity of aquatic amphibian, Bombina orientalis.
Bombina orientalis aromatase gene was subcloned into a mammalian expression vector and subsequently transfected to mammalian cells. Although the protein expression level of Bombina orientalis aromatase was low, it had a significant aromatase activity. When EDCs were added to aromatase transfected cells, aromatase activity was significantly decreased. We report here that this system may be used to monitor the effect of EDCs on aromatase activity of aquatic organisms.
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참고문헌 (22)
참고문헌 신청
Ashby J / 1998 / Uterotrophic activity of bisphenol A in the immature rat / Environmental Health Perspectives 106 : 719 ~ 720
Ashby J / 2000 / Re-evaluation of the first synthetic estrogen, 1-keto-1,2,3, 4-tetrahydrophenanthrene, and bisphenol A, using both the ovariectomised rat model used in 1933
Bonefeld-Jorgensen EC / 2004 / The human health effect programme in Greenland, a review / Science of the Total Environment 331 : 215 ~ 231
Chang CY / 1956 / Genic control and hormonal reversal of sex differentiation in Xenopus / Experimental Biology and Medicine 93 : 140 ~ 144
Chang X / 2005 / Two types of aromatase with different encoding genes, tissue distribution and developmental expression in Nile tilapia (Oreochromis niloticus) / General and
Ashby J / 2000 / Re-evaluation of the first synthetic estrogen, 1-keto-1,2,3, 4-tetrahydrophenanthrene, and bisphenol A, using both the ovariectomised rat model used in 1933
Bonefeld-Jorgensen EC / 2004 / The human health effect programme in Greenland, a review / Science of the Total Environment 331 : 215 ~ 231
Chang CY / 1956 / Genic control and hormonal reversal of sex differentiation in Xenopus / Experimental Biology and Medicine 93 : 140 ~ 144
Chang X / 2005 / Two types of aromatase with different encoding genes, tissue distribution and developmental expression in Nile tilapia (Oreochromis niloticus) / General and
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