지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Mycotoxins such as aflatoxin B1 (AFB1), ochratoxin A (OTA) and zearalenone (ZEA)are widespread contaminants of food and feedstuffs. It is very likely, that humans and animals are always exposed to mixtures of mycotoxins rather than to individual compounds. Therefore,risk assessments should consider mixture toxicity data. In the present study the combination of AFB1, OTA and ZEA was tested for genotoxicity in rat bone marrow and blood leukocytes after 15, 30 and 60 days treatment. The level of DNA damage was determined by the comet assay. The tail intensity and Olive tail moment in leukocytes and bone marrow cells were significantly higher than in controls. At the same time, the level of DNA damage in bone marrow cells was higher than in leukocytes. The data suggests that prolonged exposure to mycotoxins combination through food consumption can induce DNA damage contributing to the harmful effects in vivo.
목차
등록된 정보가 없습니다.
참고문헌 (8)
참고문헌 신청
Ben Salah-Abbes J / 2009 / Isothiocyanate from the Tunisian radish (Raphanus sativus) prevents genotoxicity of Zearalenone in vivo and in vitro / Mutat. Res 677 : 59 ~ 65
Brahmi D / 2011 / Chemopreventive effect of cactus Opuntia ficusindica on oxidative stress and genotoxicity of aflatoxin B1 / Nutr. Metab 8 : 73 ~
Kamp HG / 2005 / Ochratoxin A induces oxidative DNA damage in liver and kidney after oral dosing to rats / Mol. Nutr. Food Res 49 : 1160 ~ 1167
Ouanes Z / 2005 / Zearalenone induces chromosome aberrations in mouse bone marrow: preventive effect of 17 beta-estradiol, progesterone and Vitamin E / Mutat. Res 565 : 139 ~
Pfohl-Leszkowicz A / 2007 / Ochratoxin A: an overview on toxicity and carcinogenicity in animals and humans / Mol. Nutr. Food Res 51 : 61 ~ 99
Brahmi D / 2011 / Chemopreventive effect of cactus Opuntia ficusindica on oxidative stress and genotoxicity of aflatoxin B1 / Nutr. Metab 8 : 73 ~
Kamp HG / 2005 / Ochratoxin A induces oxidative DNA damage in liver and kidney after oral dosing to rats / Mol. Nutr. Food Res 49 : 1160 ~ 1167
Ouanes Z / 2005 / Zearalenone induces chromosome aberrations in mouse bone marrow: preventive effect of 17 beta-estradiol, progesterone and Vitamin E / Mutat. Res 565 : 139 ~
Pfohl-Leszkowicz A / 2007 / Ochratoxin A: an overview on toxicity and carcinogenicity in animals and humans / Mol. Nutr. Food Res 51 : 61 ~ 99
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