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- Cell response to genotoxic agents is complex and involves the participation of differentpresented a approach to characterize the cellular functions associated with the altered transcriptprofiles of MCF-7 exposed to low-dose in vitrogamma-irradiation. We used the method ofhuman 2.4 k cDNA microarrays containing apoptosis, cell cycle, chromatin, repair, stress andchromosome genes to analyze the differential gene expression characterization that weredisplayed by radiation- -7 cell line, such as 4 Gy 4hr, 8 Gy 4 hr, and 8 Gy 12 hr. Among these genes, 66 were up-regulated and 49 were down-regulated. Specific genes were concomitantly induced in the results. Cyclin dependent kinase 4(Cdk4) is induced for starting the cell cycle. This regulation is required for a DNA damage-induced G1 arrest. In addition to, an apoptotic pathways gene Bcl-w was concomitantly induced.Mismatch repair protein homologue-1 (hMLH1), a necessary component of DNA mismatchprotein repair (MMR), in G2-M cell cycle checkpoint arrest. The present study provides newinformation on the molecular mechanism underlying the cell response to genotoxic stress, withrelevance to basic and clinical research.
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참고문헌 (17)
참고문헌 신청
/ / Chomczynski P and N Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal. Biochem. 162 : 156 ~ 159
/ / Pratt SE and MN Pollak. 1993. Estrogen and antiestrogen modulation of MCF7 human breast cancer cell proliferation is associated with specific alterations in accumulation
Berry SE / 1840-1845. / and radiosensitization in human colon cancer cells. Cancer Res. 59
D Diamond / / JM Wozney and H Boedtker. 1977.RNA molecular weight determinations by gel electrophoresis under denaturing conditions : 4743 ~ 4751
Davis TW / / R Fishel and DA Boothman. 1998. Defective expression of the DNA mismatch repair protein alters G2-M cell cycle checkpoint arrest following ionizing radiation. Ca
/ / Pratt SE and MN Pollak. 1993. Estrogen and antiestrogen modulation of MCF7 human breast cancer cell proliferation is associated with specific alterations in accumulation
Berry SE / 1840-1845. / and radiosensitization in human colon cancer cells. Cancer Res. 59
D Diamond / / JM Wozney and H Boedtker. 1977.RNA molecular weight determinations by gel electrophoresis under denaturing conditions : 4743 ~ 4751
Davis TW / / R Fishel and DA Boothman. 1998. Defective expression of the DNA mismatch repair protein alters G2-M cell cycle checkpoint arrest following ionizing radiation. Ca
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