지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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[6]-Gingerol, a major polyphenol of ginger (Zingiber officinale), exhibits a variety of biological properties including anti-oxidant, anti-inflammatory and anti-cancer activity. However,the radioprotective effect of [6]-gingerol is still unknown. The aim of this study was to investigate the radioprotective effect of [6]-gingerol against radiation-induced cell cytotoxicity and oxidative stress in HepG2 cells. [6]-Gingerol pretreatment attenuated radiation-induced cell cytotoxicity caused by 5Gy (half lethal dose, LD50 of HepG2 cells). The measurements of superoxide dismutase (SOD) and catalase (CAT) activity were also performed. The results showed that [6]-gingerol pretreatment reduced increasing SOD and CAT activity after exposure of IR, indicating that [6]-gingerol protected oxidative stress by regulating cellular antioxidant enzyme (SOD and CAT) activity.
These findings suggest that [6]-gingerol acts as a radioprotector by attenuating cell cytotoxicity and oxidative stress.
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참고문헌 (23)
참고문헌 신청
Alia M / 2006 / Quercetin protects human hepatoma HepG2 against oxidative stress induced by tert-butyl hydroperoxide / Toxicol. Appl. Pharmacol 212 : 110 ~ 118
Bak MJ / 2012 / Antioxidant and Hepatoprotective effects of the red ginseng essential oil in H2O2- treated HepG2 cells and CCl4-treated mice / Int. J. Mol. Sci 12 : 2314 ~ 23
Bradford MM. / 1976 / Rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding / Anal. Biochem 72 :
Chakraborty D / 2012 / [6]-Gingerol isolated from ginger attenuates sodium arsenite induced oxidative stress and plays a corrective role in improving insulin signaling in mic
Chmielewski AG / 2004 / Radiation technologies: past, present and future / Radiat. Phys. Chem 71 : 16 ~ 20
Bak MJ / 2012 / Antioxidant and Hepatoprotective effects of the red ginseng essential oil in H2O2- treated HepG2 cells and CCl4-treated mice / Int. J. Mol. Sci 12 : 2314 ~ 23
Bradford MM. / 1976 / Rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding / Anal. Biochem 72 :
Chakraborty D / 2012 / [6]-Gingerol isolated from ginger attenuates sodium arsenite induced oxidative stress and plays a corrective role in improving insulin signaling in mic
Chmielewski AG / 2004 / Radiation technologies: past, present and future / Radiat. Phys. Chem 71 : 16 ~ 20
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