지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 521 - 530 (10page)
이용수
초록· 키워드
오류제보하기
Direct cell-cell communication via the transfer of small molecules between neighboring cells in tissue is accomplished by gap junctions composed of various connexins(Cxs). Proper postnatal development of the epididymis is important for acquisition of male reproduction. The epididymal epithelium is composed of several cell types, and some of these cells are connected by gap junctions. The present study was conducted to determine the presence of Cx transcripts in the corpus and cauda epididymis. In addition, transcriptional changes of Cxs expressed during different postnatal stages were examined by real-time PCR analysis. In both epididymal regions, the same nine Cx transcripts of thirteen Cxs tested were detected. In the corpus epididymis, the highest levels of Cxs31.1 and 37 transcripts were observed at 45 days of age, and amounts of Cxs26, 30.3, and 32 transcripts increased with age and subsequently decreased in the elderly. Expression of Cx31 was greatly increased in the adult and elder stages, while Cxs40, 43, and 45 were abundant in the early postnatal stages. In the cauda epididymis, expression of Cxs26, 30.3, 31.1, 37, and 40 reached the highest levels at 5 months of age. The levels of Cxs31 and 32 mRNAs fluctuated throughout the postnatal period. The amounts of Cxs43 and 45 transcripts were more abundant during the late neonatal and prepubertal ages than later ages. These findings suggest that regional specification of the epididymis is partly regulated by differential expression of Cx genes during the postnatal developmental period.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Arroteia, , K. F. / 2012 / The epididymis: embryology, structure, function and its role in fertilization and infertility. In: Embryology- Updates and Highlights on Classic Topics / In Te
Beyer, E. C. / 1995 / Cardiac intercellular communication: consequences of connexin distribution and diversity / Braz. J. Med. Biol. Res 28 : 415 ~ 425
Cry, D. G. / 1996 / Immunocytochemical localization and regulation of connexin43 in the adult rat epididymis / Endocrinology 137 : 1474 ~ 1484
Cry, D. G. / 2011 / Connexins and pannexins: coordinating cellular communication in the testis and epididymis / Spermatogenesis 1 : 325 ~ 338
Dube, E. / 2012 / Epidermal growth factor regulates connexin 43 in the human epididymis: role of gap junctions in azoospermia / Hum. Reprod 27 : 2285 ~ 2296
Beyer, E. C. / 1995 / Cardiac intercellular communication: consequences of connexin distribution and diversity / Braz. J. Med. Biol. Res 28 : 415 ~ 425
Cry, D. G. / 1996 / Immunocytochemical localization and regulation of connexin43 in the adult rat epididymis / Endocrinology 137 : 1474 ~ 1484
Cry, D. G. / 2011 / Connexins and pannexins: coordinating cellular communication in the testis and epididymis / Spermatogenesis 1 : 325 ~ 338
Dube, E. / 2012 / Epidermal growth factor regulates connexin 43 in the human epididymis: role of gap junctions in azoospermia / Hum. Reprod 27 : 2285 ~ 2296
이 논문의 저자 정보
최근 본 자료
댓글(0)
0