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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 147 - 153 (7page)
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Lipid metabolism in mature male mice may be different from immature male mice, but the relationship of lipid metabolism, especially n-6 fatty acid metabolism, and sexual maturation is not clearly established. This study was carried out to elucidate whether sexual maturation may affect the metabolism of functional n-6 fatty acids of lipid components by investigating the composition of fatty acids in the longissimus muscle tissues of mature and immature male mice with GC and analyzing the expression of genes and proteins for synthesis of n-6 fatty acids with real-time PCR and western blotting, respectively. Mature male mice showed significantly higher testosterone level in the sera. Similarly, n-6 fatty acids, levels of linoleic acid(LA 18:2n-6) and total n-6 PUFA (Polyunsaturated fatty acids) were increased, but the levels of γ-linolenic acid(GLA; 18:3n-6), dihomo-γ-linolenic acid(DGLA; 20:3n-6) and arachidonic acid(AA; 20:4 n-6) were decreased in the mature male mice. mRNA levels of Δ5-desaturase(FASD1) and elongase(ELOVL5) genes related to n-6 fatty acid metabolism increased. However, the level of FADS1 protein only increased in mature male mice. In conclusion, this study suggested that sexual maturation of male mice affected n-6 fatty acid metabolism by stimulating the expression of enzyme FADS1 of n-6 PUFA metabolism.
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참고문헌 (15)
참고문헌 신청
Barton, L. / 2011 / Effect of sex and age on bovine muscle and adipose fatty acid composition and stearoyl-CoA desaturase mRNA expression / Meat Sci 89 : 444 ~ 450
Bu, D. P. / 2007 / Effectiveness of oils rich in linoleic and linolenic acids to enhance conjugated linoleic acid in milk from dairy cows / J Dairy Sci 90 : 998 ~ 1007
Childs, C. E. / 2012 / Changes in rat n-3 and n-6 fatty acid composition during pregnancy are associated with progesterone concentrations and hepatic FADS2 expression / Prost
Childs, S. / 2008 / Effect of level of dietary n-3 polyunsaturated fatty acid supplementation on systemic and tissue fatty acid concen- trations and on selected reproductive
Guillou, H. / 2010 / The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice / Prog Lipid Res 49 : 186 ~ 199
Bu, D. P. / 2007 / Effectiveness of oils rich in linoleic and linolenic acids to enhance conjugated linoleic acid in milk from dairy cows / J Dairy Sci 90 : 998 ~ 1007
Childs, C. E. / 2012 / Changes in rat n-3 and n-6 fatty acid composition during pregnancy are associated with progesterone concentrations and hepatic FADS2 expression / Prost
Childs, S. / 2008 / Effect of level of dietary n-3 polyunsaturated fatty acid supplementation on systemic and tissue fatty acid concen- trations and on selected reproductive
Guillou, H. / 2010 / The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice / Prog Lipid Res 49 : 186 ~ 199
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