지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 419 - 425 (7page)
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초록· 키워드
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The coordinated action of the detrusor muscle cells in the urinary bladder is governed by cell-cell communication through gap junction, consisted of connexin(Cx) molecules. Even though a number of researches have been mostly focused on expressional changes of a few Cx isoforms in clinically dysfunctional condition of the bladder, less attention has been paid for investigation of Cx isoforms present in the bladder. Using real-time PCR analysis, the present study examined Cx isoforms expressing in the male rat bladder during postnatal period. Also, expressional patterns of Cx isoforms were evaluated in the bladder at different postnatal ages. Of a total of 13 Cx isoforms tested in the present study, we were able to detect mRNAs of 6 Cx isoforms in the rat urinary bladder, including Cxs 31, 31.1, 32, 37, 40, and 45. The transcript levels of Cxs 31, 31.1, 37, 40, and 45 were gradually increased from 1 week of age until 25 days of age, followed by transient decreases at 45 days of age. However, abundance of Cx32 transcript was drastically increased at 15 days of age, followed by a sharp drop at 45 days of age. These results indicate that differential expression of Cx isoforms in the bladder during postnatal development would be necessary for maintaining proper function of the bladder. A question remains to be answered if significant decreases of transcript levels of some Cx isoforms at the elderly are associated with age-dependent dysfunction of the bladder.
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참고문헌 (23)
참고문헌 신청
Allah, E. A. / 2011 / Changes in the expression of ion channels, connexins and Ca2+-handling proteins in the sino-atrial mode during postnatal development / Exp. Physiol 96 :
Evans, W. H. / 2002 / Gap junctions: structure and function (review) / Mol. Membr. Biol 19 : 121 ~ 136
Gee, J. / 2003 / Connexin 26 is abnormally expressed in bladder cancer / J. Urol 169 : 1135 ~ 1137
Giese, S. / 2012 / Sertoli-cell-specific knockout of connexin 43 leads to multiple alterations in testicular gene expression in prepubertal mice / Dis. Model. Mech
Goodenough, D. A. / 2009 / Gap junctions / Cold Spring Harb. Perspect. Biol 1 : a003061 ~
Evans, W. H. / 2002 / Gap junctions: structure and function (review) / Mol. Membr. Biol 19 : 121 ~ 136
Gee, J. / 2003 / Connexin 26 is abnormally expressed in bladder cancer / J. Urol 169 : 1135 ~ 1137
Giese, S. / 2012 / Sertoli-cell-specific knockout of connexin 43 leads to multiple alterations in testicular gene expression in prepubertal mice / Dis. Model. Mech
Goodenough, D. A. / 2009 / Gap junctions / Cold Spring Harb. Perspect. Biol 1 : a003061 ~
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