지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 411 - 418 (8page)
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초록· 키워드
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KIT gene is the major causative gene for coat color variation in diverse animal species. This gene regulates melanocyte migration from the neural crest to target tissues and the mutation of this gene can affect dominant white phenotypes in animals. Because this gene has a major influence for the coat color variation, single nucleotide polymorphisms(SNPs) in 14 Korean cattle (Hanwoo) and 5 Holstein individuals were investigated. The Hanwoo DNA samples included three different colored(5 Black, 5 Yellow and 4 Stripe) animals. Total 126 polymorphisms have been identified and 23 of them are located in the exon region. Also, 5 bp(TTCTC) and 3 bp(TCT) intronic indels in intron 3 and intron 5, respectively, were identified. Out of 23 exonic polymorphisms, 15 SNPs are the missense mutations and the rest of the SNPs are silence mutations. The neighbor-joining phylogenetic tree was constructed for the different colored animals using the obtained KIT gene sequences. Holstein breed showed a clear breed-specific cluster in the phylogenetic tree which is differed from Hanwoo. Also, three colored Hanwoo animals were not discriminated among the breeds. The KIT gene polymorphisms identified in this study will possibly give some solutions for the color variations in cattle with further verifications.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Besmer, P. / 1993 / The kit-ligand(steel factor) and its receptor c-kit/W: pleiotropic roles in gametogenesis and melanogenesis / Dev. Suppl : 125 ~ 137
Brooks, S. A. / 2005 / Exon skipping in the KIT gene causes a Sabino spotting pattern in horses / Mamm. Genome 16 : 893 ~ 902
Chabot, B. / 1988 / The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus / Nature 335 : 88 ~ 89
Fleischman, R. A. / 1991 / Deletion of the c-kit protooncogene in the human developmental defect piebald trait / Proc. Natl. Acad. Sci. U. S. A 88 : 10885 ~ 10889
Fontanesi, L. / 2009 / Genetic heterogeneity at the bovine KIT gene in cattle breeds carrying different putative alleles at the spotting locus / Anim. Genet 41 : 295 ~ 303
Brooks, S. A. / 2005 / Exon skipping in the KIT gene causes a Sabino spotting pattern in horses / Mamm. Genome 16 : 893 ~ 902
Chabot, B. / 1988 / The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus / Nature 335 : 88 ~ 89
Fleischman, R. A. / 1991 / Deletion of the c-kit protooncogene in the human developmental defect piebald trait / Proc. Natl. Acad. Sci. U. S. A 88 : 10885 ~ 10889
Fontanesi, L. / 2009 / Genetic heterogeneity at the bovine KIT gene in cattle breeds carrying different putative alleles at the spotting locus / Anim. Genet 41 : 295 ~ 303
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