지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 203 - 209 (7page)
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초록· 키워드
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Lysophosphatidic acid(LPA) is a small lipid molecule that plays an important role through LPA receptors(LPARs) in reproductive processes. Our previous study has shown maximal expression of LPAR3 in the uterine endometrium on day(D) 12 of pregnancy in pigs, the period when conceptus secretes various molecules such as estrogen and interleukin-1β(IL1B) and initiates implantation. We determined that endometrial expression of LPAR3 was increased by conceptus estrogen in the previous study, but the effect of IL1B on LPAR3 expression has not been determined. Thus, in this study we examined whether LPAR3 expression was also affected by IL1B. Endometrial explant cultures from D12 of the estrous cycle showed that levels of endometrial LPAR3 expression did not changed in response to IL1B. We also investigated LPAR3 expression in the uterine endometrium on D12 and D30 of pregnancy from gilts with conceptuses derived from somatic cell nuclear transfer(SCNT). The expression of LPAR3 mRNA was lower in endometria from gilts with conceptuses resulting from SCNT compared with those from gilts with embryos resulting from natural mating on D12 of pregnancy, but it was not different between them on D30 of pregnancy. Our results indicate that estrogen of conceptus origin is responsible for induction of LPAR3 expression during the peri-implantation period and appropriate LPA signaling is impaired in the uterine endometrium with SCNT-derived conceptuses during the implantation period in pigs.
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참고문헌 (22)
참고문헌 신청
/ 200812 / Analysis of Lysophosphatidic Acid (LPA) Receptor and LPA-Induced Endometrial Prostaglandin-Endoperoxide Synthase 2 Expression in the Porcine Uterus / Endocrinolog
Bauersachs, S / 2009 / The endometrium responds differently to cloned versus fertilized embryos / Proc. Natl. Acad. Sci. U S A 106 : 5681 ~ 5686
Bazer, F. W / 1998 / Endocrinology of the transition from recurring estrous cycles to establishment of pregnancy in subprimate mammals. In Endocrinology of pregnancy / Humana Press, New
Bowen, J. A / 2000 / Cellular mechanisms of implantation in domestic farm animals / Semin. Cell. Dev. Biol 11 : 93 ~ 104
Burghardt, R. C / 1997 / Extracellular matrix and the implantation cascade in pigs / J. Reprod. Fertil. Suppl 52 : 151 ~ 164
Bauersachs, S / 2009 / The endometrium responds differently to cloned versus fertilized embryos / Proc. Natl. Acad. Sci. U S A 106 : 5681 ~ 5686
Bazer, F. W / 1998 / Endocrinology of the transition from recurring estrous cycles to establishment of pregnancy in subprimate mammals. In Endocrinology of pregnancy / Humana Press, New
Bowen, J. A / 2000 / Cellular mechanisms of implantation in domestic farm animals / Semin. Cell. Dev. Biol 11 : 93 ~ 104
Burghardt, R. C / 1997 / Extracellular matrix and the implantation cascade in pigs / J. Reprod. Fertil. Suppl 52 : 151 ~ 164
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