지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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We previously have reported that periglomerular calponin expression of the glo-merulosclerotic glomeruli in the chronic nephropathy. To investigate the role of calponin during glomerulosclerosis, we examined the detailed localization pattern of calponin in chronic nephropathy rat model using serial morphometric analysis. Male Sprague-Dawley rats were used, and chronic nephropathy models were established at 8 and 12 weeks after single intraperitoneal injection of adriamycin (10 mg/kg body weight; n=5). In nephropathy models, 16.3% (8 weeks) and 23.4% (12 weeks) glomeruli showed calponin-positivity at glomerular area. In all these glomeruli, showing various sclerotic changes, calponin-immunoreactivities were present only both the glomerular parietal epithelial cells (PECs) and periglomerular myoἀbroblasts (PMFs). However, in the glomeruli with weak calponin-positive, immunoreactivity was mostly detected in PECs, suggesting that calponin may be expressed in PECs earlier than in PMFs in the glomerulosclerotic change. Some calponin-positive PECs invaded glomerular tuft with loop-shaped projection, and around this projection, nestin expression of glomerular tuft were much reduced. These results suggested that calponin-positive PECs may play a key role in the development of glomerulosclerosis, and direct contact with PECs and glomerular tuft may be more important to degenerative changes of glomeruli.
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참고문헌 (16)
참고문헌 신청
Bohle A, Mackensen-Haen S / 1987 / Significance of tubulointerstitial changes in the renal cortex for the excretory function and concentration ability of the kidney: a morpho
Cha J H / 2001 / Hydration status affects nuclear distribution of transcription factor tonicity responsive enhancer binding protein in rat kidney / J. Am. Soc. Nephrol 12 : 2
Dijkman H / 2005 / The parietal epithelial cell is crucially involved in human idiopathic focal segmental glomerulosclerosis / Kidney Int 68 : 1562 ~ 1572
El Nahas A M / 1996 / Glomerulosclerosis: intrinsic and extrinsic pathways / Nephrol. Dial. Transplant 11 : 773 ~ 777
Guan N / 2004 / Key molecular events in puromycin aminonucleoside nephrosis rats / Pathol. Int 54 : 703 ~ 711
Cha J H / 2001 / Hydration status affects nuclear distribution of transcription factor tonicity responsive enhancer binding protein in rat kidney / J. Am. Soc. Nephrol 12 : 2
Dijkman H / 2005 / The parietal epithelial cell is crucially involved in human idiopathic focal segmental glomerulosclerosis / Kidney Int 68 : 1562 ~ 1572
El Nahas A M / 1996 / Glomerulosclerosis: intrinsic and extrinsic pathways / Nephrol. Dial. Transplant 11 : 773 ~ 777
Guan N / 2004 / Key molecular events in puromycin aminonucleoside nephrosis rats / Pathol. Int 54 : 703 ~ 711
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