지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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The study examined the antioxidant activities and anti-inflammatory effects of rutin from the streptozotocin (STZ)-induced diabetic rats. Results revealed that the levels of plasma glucose and serum glucose were remarkably higher in the STZ-treated group compared to other groups and were significantly reduced in the STZ+rutin treated group compared to the STZ-treated group. In terms of weight, it significantly increased in all experimental groups during the experiment period except for STZ-induced diabetic group. The weight of the STZ-treated group was remarkably reduced compared to other groups. Regarding the weight of each body organ, the STZ-treated group showed higher organ weight compared to the other groups while STZ+rutin-treated group showed significantly reduced kidney and liver weights compared to those of STZ-treated group. In the pancreas tissue of the STZ-treated group, β-cell destruction and vacuolization were observed. Inflammation in the heart, liver, kidney, and retina tissues were also vividly recorded. In the STZ+rutin administered group, the heart and retina tissues were shown to be preserved normally while the liver and kidney tissues showed reduced histopathology in general compared to the STZ-treated group. Conclusionally, the rutin has the effect on the antioxidant activities and anti-inflammation in the STZ-induced diabetic rats.
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참고문헌 (24)
참고문헌 신청
Ahmed I / 1998 / Effects of Momordica charantia fruit juice on islet morphology in the pancreas of the streptozotocin-diabetic rat / Diabetes Res. Clin. Pract 40 : 145 ~ 151
Aleksandrov P N / 1986 / Effect of rutin and esculamine on models of aseptic inflammation / Farmakol. Toksikol 49 : 84 ~ 86
Aronson D / 2004 / Obesity is the major determinant of elevated C-reactive protein in subjects with the metabolic syndrome / Int. J. Obes. Relat. Metab. Disord 28 : 674 ~ 679
Baynes J W / 1991 / Role of oxidative stress in development of complications in diabetes / Diabetes 40 : 405 ~ 412
Bear W L / 2000 / Effects of citrus flavonoids on the mutagenicity of heterocyclic amines and on cytochrome P450 1A2 activity / Anticancer Res 20 : 3609 ~ 3614
Aleksandrov P N / 1986 / Effect of rutin and esculamine on models of aseptic inflammation / Farmakol. Toksikol 49 : 84 ~ 86
Aronson D / 2004 / Obesity is the major determinant of elevated C-reactive protein in subjects with the metabolic syndrome / Int. J. Obes. Relat. Metab. Disord 28 : 674 ~ 679
Baynes J W / 1991 / Role of oxidative stress in development of complications in diabetes / Diabetes 40 : 405 ~ 412
Bear W L / 2000 / Effects of citrus flavonoids on the mutagenicity of heterocyclic amines and on cytochrome P450 1A2 activity / Anticancer Res 20 : 3609 ~ 3614
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