지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Cytokeratin 19 (CK19) expressed in epidermis of skin, bulge region of hair follicle, outermost layer of outer root sheath and proximal and distal to bulge. Vimentin is a fibrous protein that localized in cytoplasm of fibroblast and forms cytoskeleton to maintain shape of cell and nucleus. In this study, CK19 and vimentin in skin were confirmed with light, fluorescence and transmission electron microscope. As a result, CK19 was localized epidermis, hair follicles, outer root sheath and nucleus of Merkel’s cell. However, vimentin was localized some epidermis, dermis, hypodermis and nucleus of Merkel’s cell. The role of CK19 is self-renewal and homeostasis in skin. Also, hair follicle regeneration and hair growth is known to be related. It is supposed that required of structural proteins that make up cytoskeleton is increased. Thereby, expression of CK19 is increased. It is considered that vimentin localized in order to stabilize structure of cell and cytoskeleton of fibroblasts. Also, CK19 and vimentin present in nuclei of Merkel’s cell, and to act as a fibrous protein that make up end of a nerve fiber present in Merkel’s cell and paracrine function of Merkel’s cell.
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참고문헌 (25)
참고문헌 신청
Abbas O / 2009 / Epidermal stem cells: practical perspectives and potential uses / Br. J. Dermatol 161 : 228 ~ 236
Abbas O / 2011 / Stem cell markers (cytokeratin 15, cytokeratin 19 and p63) in in situ and invasive cutaneous epithelial lesions / Modern Pathology 24 : 90 ~ 97
Bartek J / 1985 / Patterns of expression of keratin 19 as detected with monoclonal antibodies in human breast tissues and tumours / Int. J. Cancer 36 : 299 ~ 306
Fradette J / 1995 / Localization of Merkel cells at hairless and hairy human skin sites using keratin 18 / Biochem. Cell Biol 73 : 635 ~ 639
Goldman R D / 1973 / Functions of cytoplasmic fibers in non-muscle cell motility. Cold Spring Harbor Symp. Quant. Biol / Cold Spring Harbor Symp. Quant. Biol 37 : 523 ~ 534
Abbas O / 2011 / Stem cell markers (cytokeratin 15, cytokeratin 19 and p63) in in situ and invasive cutaneous epithelial lesions / Modern Pathology 24 : 90 ~ 97
Bartek J / 1985 / Patterns of expression of keratin 19 as detected with monoclonal antibodies in human breast tissues and tumours / Int. J. Cancer 36 : 299 ~ 306
Fradette J / 1995 / Localization of Merkel cells at hairless and hairy human skin sites using keratin 18 / Biochem. Cell Biol 73 : 635 ~ 639
Goldman R D / 1973 / Functions of cytoplasmic fibers in non-muscle cell motility. Cold Spring Harbor Symp. Quant. Biol / Cold Spring Harbor Symp. Quant. Biol 37 : 523 ~ 534
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