지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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ICI 182,780 (ICI) is known as an estrogen receptor antagonist, whereas propyl pyrazole triol (PPT) is an estrogen receptor agonist. In this study, ICI or ICI added with PPT was injected into adult male mice. Body and reproductive organ weights were reduced in the ICI added with PPT group compared to the control group. Further, the ICI and ICI added with PPT groups both showed increases in luminal areas of the seminiferous tubules of the testis, whereas cell heights of efferent ductules and the initial segment of the epididymis were reduced. Sperm count in the caudal epididymis was reduced in the ICI and ICI added with PPT groups. These results show that reproductive tissues were more deeply affected in the ICI added with PPT group. We also demonstrated that treatment with ICI resulted in histological changes in the testis, efferent ductule, and epididymis. Further, alternate treatment with ICI and PPT induced abnormalities in reproductive organs. These results indicate that a high concentration of PPT together with ICI may cause histological abnormalities instead of histological restoration in reproductive organs.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Aleem M / 2006 / Estradiol affects androgen-binding protein expression and fertilizing ability of spermatozoa in adult male rats / Mol. Cell. Endocrinol 253 : 1 ~ 13
Carreau S / 2007 / Estrogens and male reproduction: a new concept / Braz. J. Med. Biol. Res 40 : 761 ~ 768
Cho H W / 2003 / The antiestrogen ICI 182,780 induces early effects on the adult male mouse reproductive tract and long-term decreased fertility without testicular atrophy /
Clipperton-Allen A E / 2011 / Effects of an estrogen receptor alpha agonist on agonistic behavior in intact and gonadectomized male and female mice / Psyneuen 36 : 981 ~ 995
Cook J C / 1998 / Effects of dietary 17 beta-estradiol exposure on serum hormone concentrations and testicular parameters in male Crl:CD BR rats / Toxicol. Sci 44 : 155 ~ 168
Carreau S / 2007 / Estrogens and male reproduction: a new concept / Braz. J. Med. Biol. Res 40 : 761 ~ 768
Cho H W / 2003 / The antiestrogen ICI 182,780 induces early effects on the adult male mouse reproductive tract and long-term decreased fertility without testicular atrophy /
Clipperton-Allen A E / 2011 / Effects of an estrogen receptor alpha agonist on agonistic behavior in intact and gonadectomized male and female mice / Psyneuen 36 : 981 ~ 995
Cook J C / 1998 / Effects of dietary 17 beta-estradiol exposure on serum hormone concentrations and testicular parameters in male Crl:CD BR rats / Toxicol. Sci 44 : 155 ~ 168
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