지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Inflammatory cells express the inflammatory cytokines and growth factors induced by lipopolysaccharide (LPS). Odontoblasts are located at the pulp–dentin interface and extend their cell processes far into the dentin where they are the first cells to encounter microorganisms or their products. Therefore, this study examined the expression of some growth factors related to the signal pathway, such as growth factor receptor binding protein 2 (Grb2)-Ras in odontoblast-like dental pulp cells, after a treatment with LPS. After 60 minutes, the mRNA and protein expression levels of Grb2 and Ras were higher in the LPS-treated cells than in the control cells. The level of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) mRNA expression was increased significantly to a level similar to that of Grb2 and Ras at 60 minutes. The platelet-derived growth factor-AA (PDGF-AA) mRNA level was expressed strongly in the odontoblast like dental pulp cells without an association with LPS stimulation. Scanning electron microscopy revealed many extensions of the cytoplasmic processes and the number of processes increased gradually at 30, 60 and 90 minutes after LPS stimulation. From these results VEGF and bFGF expression might be induced through the Grb2-Ras signal transduction pathway in LPS treated odontoblasts.
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참고문헌 (23)
참고문헌 신청
Arvidsson A K / 1994 / Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation / Mol. Cell. Biol 14 : 6715 ~
Balic A / 2010 / Characterization of progenitor cells in pulps of murine incisors / J. Dent. Res 89 : 1287 ~ 1292
Balic A / 2010 / Characterization of stem and progenitor cells in the dental pulp of erupted and unerupted murine molar / Bone 46 : 1639 ~ 1651
Berra E / 2000 / MAP kinases and hypoxia in the control of VEGF expression / Cancer Metastasis Rev 19 : 139 ~ 145
Bornfeldt K E / 1995 / Platelet-derived growth factor. Distinct signal transduction pathways associated with migration versus proliferation / Ann. N. Y. Acad. Sci 766 : 416 ~
Balic A / 2010 / Characterization of progenitor cells in pulps of murine incisors / J. Dent. Res 89 : 1287 ~ 1292
Balic A / 2010 / Characterization of stem and progenitor cells in the dental pulp of erupted and unerupted murine molar / Bone 46 : 1639 ~ 1651
Berra E / 2000 / MAP kinases and hypoxia in the control of VEGF expression / Cancer Metastasis Rev 19 : 139 ~ 145
Bornfeldt K E / 1995 / Platelet-derived growth factor. Distinct signal transduction pathways associated with migration versus proliferation / Ann. N. Y. Acad. Sci 766 : 416 ~
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