지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Human placenta extract (hPE) has therapeutic potential against certain diseases such as burn injury, liver cirrhosis and chronic wound through stimulating tissue repair processes. However, the effects of hPE on liver regeneration in animals are unknown.
This study investigated the effect of hPE on the expression of proliferating cell nuclear antigen (PCNA) during liver regeneration induced by partial hepatectomy (PH) in rats.
The activities of AST, ALT and ALP increased during a few days after PH. A high level of ALP was particularly seen at day 3 in the control group. All the levels of experimental groups were normalized by day 5 after PH. On immunohistochemistry, the expression of PCNA increased at the early days, showed a peak at day 3 after PH. The PCNA staining was more obvious in the experimental group over the whole period. By western blotting,PCNA seemed to be more strongly expressed in the hPE injected group in the early stage and fell to almost undetectable levels at day 7. On immunocytochemical observations, the number of PCNA-gold particles in the nuclei at day 1 of the hPE treated groups was more than those of the untreated groups. The results suggest that hPE could accelerate liver regeneration induced by PH involving the expression of PCNA in rats.
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참고문헌 (24)
참고문헌 신청
Amemiya H / 2011 / Liver regeneration is impaired in macrophage colony stimulating factor defi cient mice after partial hepatectomy: the role of M-CSF-induced macrophages / J
Ansari K U / 1994 / An experimental and clinical evaluation of immuno-modulating potential of human placental extract / Indian J. Pharmacol 26 : 130 ~ 132
Assy N / 1997 / Liver regeneration: methods for monitoring and their aplications / J. Hepatol 26 : 945 ~ 952
Assy N / 1998 / Use of proliferating cell nuclear antigen as a marker of liverregeneration after partial hepatectomy in rats / J. Lab. Clin. Med 131 : 251 ~ 256
Bockhorn M / 2007 / VEGF is important for early liver regeneration after partial hepatectomy / J. Surg. Res 138 : 291 ~ 299
Ansari K U / 1994 / An experimental and clinical evaluation of immuno-modulating potential of human placental extract / Indian J. Pharmacol 26 : 130 ~ 132
Assy N / 1997 / Liver regeneration: methods for monitoring and their aplications / J. Hepatol 26 : 945 ~ 952
Assy N / 1998 / Use of proliferating cell nuclear antigen as a marker of liverregeneration after partial hepatectomy in rats / J. Lab. Clin. Med 131 : 251 ~ 256
Bockhorn M / 2007 / VEGF is important for early liver regeneration after partial hepatectomy / J. Surg. Res 138 : 291 ~ 299
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