지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Polycystic ovary syndrome (PCOS) is hormonal imbalance condition as the endocrine and metabolic disorder that induces the infertility and various complications in reproductive age women. Estradiol valerate (EV) is used hormone replacement therapy in menopausal women and is reported that excessive administration of EV induces the PCOS. Nerve growth factor (NGF) is the factor to regulate the survival and maturation of developing neuronal cell and is also synthesized in ovary.
And NGF is overexpressed in EV-induced polycystic ovary (PCO) as previously reported. Therefore, this study examined the possibility of NGF as can be used the biological marker in diagnosis of PCOS, the hormonal imbalance condition,using PCO and CHO (chinese hamster ovarian) cell lines. The concentration of EV treatment is optimized a 1 mg as not influence on the proliferation of CHO cell but 2 mg and 3 mg of EV treatment have the inhibition effect at initial stage.
The morphological change was not observed in CHO cell after dose dependent manner treatment of EV. Expression of NGF mRNA and protein is significantly increased at 30 min after EV treatment in CHO cells compared to that of control.
And NGF protein expression is strongly increased in PCO tissue, which observed many follicular cysts compared to normal ovary tissue. Taken together, overexpression of NGF may be act as a molecule to induce an abnormal development of follicle, suggesting that NGF can be used as a biological marker in diagnosis of PCOS.
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참고문헌 (24)
참고문헌 신청
Amato G / 2003 / Serum and follicular fluid cytokines in polycystic ovary syndrome during stimulated cycles / Obstet Gynecol 101 : 1177 ~ 1182
Artini PG / 2007 / Growth factors and folliculogenesis in polycystic ovary patients / Expert Rev Endocrinol Metab 2 : 215 ~ 223
Balen AH / 1999 / The pathogenesis of polycystic ovary syndrome: the enigma unravels / Lancet 354 : 966 ~ 967
Barria A / 1993 / Ovarian steroidal response to gonadotropins and beta-adrenergic stimulation is enhanced in polycystic ovary syndrome: role of sympathetic innervation / Endo
Conner P / 2005 / Expression of p53 and markers for apoptosis in breast tissue during long-term hormone therapy in cynomolgus monkeys / Am J Obstet Gynecol 193 (1) : 58 ~ 63
Artini PG / 2007 / Growth factors and folliculogenesis in polycystic ovary patients / Expert Rev Endocrinol Metab 2 : 215 ~ 223
Balen AH / 1999 / The pathogenesis of polycystic ovary syndrome: the enigma unravels / Lancet 354 : 966 ~ 967
Barria A / 1993 / Ovarian steroidal response to gonadotropins and beta-adrenergic stimulation is enhanced in polycystic ovary syndrome: role of sympathetic innervation / Endo
Conner P / 2005 / Expression of p53 and markers for apoptosis in breast tissue during long-term hormone therapy in cynomolgus monkeys / Am J Obstet Gynecol 193 (1) : 58 ~ 63
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