지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Purpose: This study compared the performance of new NONMEM estimation methods using a population analysis dataset collected from a clinical study that consisted of 40 individuals and 567 observations after a single oral dose of glimepiride. Method: The NONMEM 7.2 estimation methods tested were first-order conditional estimation with interaction (FOCEI), importance sampling (IMP), importance sampling assisted by mode a posteriori (IMPMAP), iterative two stage (ITS), stochastic approximation expectation-maximization (SAEM), and Markov chain Monte Carlo Bayesian (BAYES) using a two-compartment open model. Results: The parameters estimated by IMP, IMPMAP, ITS, SAEM, and BAYES were similar to those estimated using FOCEI, and the objective function value (OFV) for diagnosing the model criteria was significantly decreased in FOCEI, IMPMAP, SAEM, and BAYES in comparison with IMP. Parameter precision in terms of the estimated standard error was estimated precisely with FOCEI, IMP, IMPMAP, and BAYES. The run time for the model analysis was shortest with BAYES. Conclusion: In conclusion, the new estimation methods in NONMEM 7.2 performed similarly in terms of parameter estimation, but the results in terms of parameter precision and model run times using BAYES were most suitable for analyzing this dataset.
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참고문헌 (5)
참고문헌 신청
Gibiansky L / 2012 / Comparison of Nonmem 7.2 estimation methods and parallel processing efficiency on a target-mediated drug disposition model / Pharmacokinet Pharmacodyn 39
Gyujeong Noh / 2011 / NONMEM 7 기술 안내서
Gyujeong Noh / 2011 / NONMEM 7.2.0 사용자 안내서
Karlsson KE / 2011 / Performance of three estimation methods in time-to-event modeling / AAPS J 13 (1) : 83 ~ 91
Yoo HD / 2011 / Population pharmacokinetic analysis of glimepiride with CYP2C9 genetic polymorphism in healthy subjects / Eur J Clin Pharmacol 67 (9) : 889 ~ 898
Gyujeong Noh / 2011 / NONMEM 7 기술 안내서
Gyujeong Noh / 2011 / NONMEM 7.2.0 사용자 안내서
Karlsson KE / 2011 / Performance of three estimation methods in time-to-event modeling / AAPS J 13 (1) : 83 ~ 91
Yoo HD / 2011 / Population pharmacokinetic analysis of glimepiride with CYP2C9 genetic polymorphism in healthy subjects / Eur J Clin Pharmacol 67 (9) : 889 ~ 898
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