지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objective: To evaluate the clinical manifestations and causative drugs of the outpatient adverse drug reactions (ADRs)reported by community pharmacy. Methods: From April 2013 to September 2013, all outpatient ADRs reported bycommunity pharmacy to Regional Pharmacovigilance Center of Korean Pharmaceutical Association were included. Thecausality of ADRs was assessed by the criteria of WHO-Uppsala Monitoring Centre. The clinical features and theoffending drugs were analyzed using the WHO-Adverse Reaction Terminology and the classification of American HospitalFormulary Service Drug Information, respectively. Results: 2,826 (97.0%) of the total 2,912 ADRs had causalrelationship. The 1,923 patients with mean age of 55.1 years and female fraction of 66.5% were included in the ADRs. Gastrointestinal (33.6%), nervous system (14.9%), and skin (13.5%) symptoms were common in ADRs. Analgesicdrugs (19.7%), gastrointestinal drugs (17.7%), and central nervous system drugs (11.0%) were prevalent offendingdrugs. The leading causative generic drug was the complex of acetaminophen and tramadol. Among 203 ADRs by thenonprescription drugs, the most common clinical features were skin (37.4%) and gastrointestinal (23.6%) symptoms andthe most prevalent offending drugs were analgesic drugs (40.0%) and mucocutaneous system drugs (16.3%). The combinationof acetaminophen and chlorzoxazone was the leading causative generic in nonprescription drugs. Conclusion:In this study, gastrointestinal symptom was the most common manifestation and analgesic drug was the most commoncausative drug in outpatient ADRs reported by community pharmacy.
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참고문헌 (28)
참고문헌 신청
American Society of Health-System Pharmacists(ASHP) / 2013 / AHFS Drug Information 2013 / ASHP
Bates DW. / 1997 / The costs of adverse drug events in hospitalized patients. Adverse Drug Events Prevention Study Group / JAMA 277 (4) : 307 ~ 311
Bourgeois FT. / 2010 / Adverse drug events in the outpatient setting : an 11-year national analysis / Pharmacoepidemiol Drug Saf 19 (9) : 901 ~ 910
Cohen AL. / 2008 / National surveillance of emergency department visits for outpatient adverse drug events in children and adolescents / J Pediatr 152 (3) : 416 ~ 421
Cosentino M. / 1999 / Hospital-based survey of doctors' attitudes to adverse drug reactions and perception of drug-related risk for adverse reaction occurrence / Pharmacoepi
Bates DW. / 1997 / The costs of adverse drug events in hospitalized patients. Adverse Drug Events Prevention Study Group / JAMA 277 (4) : 307 ~ 311
Bourgeois FT. / 2010 / Adverse drug events in the outpatient setting : an 11-year national analysis / Pharmacoepidemiol Drug Saf 19 (9) : 901 ~ 910
Cohen AL. / 2008 / National surveillance of emergency department visits for outpatient adverse drug events in children and adolescents / J Pediatr 152 (3) : 416 ~ 421
Cosentino M. / 1999 / Hospital-based survey of doctors' attitudes to adverse drug reactions and perception of drug-related risk for adverse reaction occurrence / Pharmacoepi
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