지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: It is recommended to use aerosolized (AS) colistin in patients undergoing mechanical ventilation therapy as anadjunctive in the latest guidelines, in spite of high nephrotoxicity and limited studies. In this study, systematic reviews and metaanalyzeswere conducted to evaluate the safety and efficacy of AS colistin in patients with ventilator-associated pneumoniaMethods: Two authors independently searched related literature published from Pubmed and EMBASE until July 2016 and includeda study comparing adjunctive AS colistin with intravenous (IV) colistin monotherapy. The primary outcome was the clinical responserate, the secondary outcome was the overall mortality, and nephrotoxicity. The publication bias was evaluated using the Egger'stest. Results: Of the total 279 articles, nine were finally included in the final analysis. There was a significant difference between theadjunctive AS colistin group and the IV colistin monotherapy group for the treatment-response rate (odds ratio (OR), 1.56; 95% CI,1.14-2.14; p = 0.005; I2 = 36%), although there was no significant difference in overall mortality (OR, 0.77; 95% CI, 0.57-1.04; p =0.09; I2 = 20%). However, there was no significant difference between the two groups in nephrotoxicity (OR, 1.13; 95% CI, 0.74-1.74;p = 0.57; I2 = 4%). Conclusion: The addition of aerosolized colistin to IV colistin monotherapy showed better results in terms ofefficacy than IV colistin monotherapy and did not show any significant difference in terms of total mortality and nephrotoxicity.
Additional large-scale studies of this need to be verified.
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참고문헌 (21)
참고문헌 신청
Chemical Sciences R / 2014 / The National Academies Collection: Reports funded by National Institutes of Health / Technological Challenges in Antibiotic Discovery and Development:
Egger M / 1997 / Bias in meta-analysis detected by a simple, graphical test / BMJ (Clinical research ed) 315 (7109
Higgins J / 2015 / Cochrane Handbook for Systematic Reviews of Interventions Version 5.1. 0 [updated March 2011] / The Cochrane Collaboration
Higgins JP / 2003 / Measuring inconsistency in meta-analyses / BMJ(Clinical research ed) 327 (7414) : 557 ~ 560
Imberti R / 2010 / Steady-state pharmacokinetics and BAL concentration of colistin in critically Ill patients after IV colistin methanesulfonate administration / CHEST 138 (
Egger M / 1997 / Bias in meta-analysis detected by a simple, graphical test / BMJ (Clinical research ed) 315 (7109
Higgins J / 2015 / Cochrane Handbook for Systematic Reviews of Interventions Version 5.1. 0 [updated March 2011] / The Cochrane Collaboration
Higgins JP / 2003 / Measuring inconsistency in meta-analyses / BMJ(Clinical research ed) 327 (7414) : 557 ~ 560
Imberti R / 2010 / Steady-state pharmacokinetics and BAL concentration of colistin in critically Ill patients after IV colistin methanesulfonate administration / CHEST 138 (
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