지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Licorice is a very useful herbal medicine frequently prescribed, but glycyrrhizin, one of its components, can cause pseudoaldosteronism presenting hypokalemia, metabolic alkalosis and hypertension as a result of prolonging a biological half-life of systemic steroid by strongly inhibiting the enzyme 11β-hydroxysteroid dehydrogenase type 2. The risk factors for this side effect are still unclear. Here, 479 hospitalized patients taking herbal medicines including licorice for more than five days were recruited to analyze their serum potassium levels, under following parameters ; age and gender of patient, dose and period of licorice, disease state such as hypertension and with or without diuretics. They were divided into the non-occurrence group (over 3.5 mEq/L) and the occurrence group (under 3.5 mEq/L) of hypokalemia based on serum potassium levels during hospitalization. The average ages of the non-occurrence group and the occurrence group were 52.6±17.8 and 68±10.5, respectively (p < 0.001). But there were no noticeable differences in the daily dose of licorice, days of taking, and total dose between groups. Regression analysis showed that odd ratio of age (>60)and taking diuretics inducing hypokalemia was 3.5 (95%CI 1.5-8.1), 4.6 (95%CI 2.0-10.9) that indicates significant correlation with hypokalemia. Based upon this analysis, it is imperative to monitor regularly the risk of pseudoaldosteronism or hypokalemia not only when administered licorice of high dose for long period but also when combined it with diuretics causing hypokalemia to the elderly patients over 60 year old
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참고문헌 (23)
참고문헌 신청
Akao T / 1988 / Glycyrrhizin stimulates growth of Eubaterium sp. Strain GLH, a human intestinal anaerobe / Applied and environmental microbiology : 2027 ~ 2030
Cayley FEW / 1950 / Potassium deficiency in p-amino-salicylic acid therapy. Cardiac and paralytic effect / Lancet I : 447 ~ 448
Conn JW / 1968 / Licorice-induced psedoaldosteronism / JAMA 205 : 492 ~ 496
Dehpour AR / 1994 / The protective effect of liquorice components and their derivatives against gastric ulcer induced by aspirin in rats / J Pharm Pharmacol 46 (2) : 148 ~ 14
Ferrari P / 2009 / Licorice : a sweet alternative to prevent hyperkalemia in dialysis patients? / Kidney International 76 : 811 ~ 812
Cayley FEW / 1950 / Potassium deficiency in p-amino-salicylic acid therapy. Cardiac and paralytic effect / Lancet I : 447 ~ 448
Conn JW / 1968 / Licorice-induced psedoaldosteronism / JAMA 205 : 492 ~ 496
Dehpour AR / 1994 / The protective effect of liquorice components and their derivatives against gastric ulcer induced by aspirin in rats / J Pharm Pharmacol 46 (2) : 148 ~ 14
Ferrari P / 2009 / Licorice : a sweet alternative to prevent hyperkalemia in dialysis patients? / Kidney International 76 : 811 ~ 812
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