지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objective: To report a fatal case of Multidrug-resistant Acinetobacter baumannii (MDR-AB) in a patient with interstitial lung disease (ILD) on high-dose glucocorticoids.
Case Summary: A 66-year-old man with a history of coniosis was transferred to the hospital with progressive cough and sputum production. This patient has been diagnosed with pneumonia and ILD on admission, requires antimicrobial therapy and systemic immunosuppressants. He received high dose of methylprednisolone and cyclophosphamide for ILD as well as ceftriaxone and azithromycin for pneumonia. On day 7 in the intensive care units (ICUs), patient had fever and leukocytosis, thus antimicrobials were switched to piperacillin. After 13 days in the ICU, Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus (MRSA) were isolated on transtracheal aspirate (TTA) and meropenem was initiated. However, it was revealed a multidrug-resistant Acinetobacter baumannii (MDR-AB) species, resistant to carbapenem.
Patient was administered colistin but expired due to septic shock on day 84.
Discussion: Systemic immunosuppressive therapy can result in infections that may compromise patient’s survival.
MDR-AB has emerged as a serious cause of nosocomial infections in immunocompromised patients. MDR-AB is resistant to most standard antimicrobials and therapeutic options are limited.
Conclusion: We report our recent experience with a fatal MDR-AB pneumonia in a patient with ILD, who had to be treated with high dose glucocorticoids and immunosuppressnts.
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참고문헌 (23)
참고문헌 신청
/ / Food and Drug Administration Web site: Colistimethate Information
/ / Micromedex Healthcare Series Web site
Bergogne-Berezin E / 1996 / Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features / Clin Microbiol Rev 9 : 148 ~ 165
Bonomo RA / 2006 / Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa / Clin Infect Dis 43 (Suppl 2) : 49 ~ 56
Falagas ME / 2006 / The diversity of definitions of multidrug-resistant (MDR) and pandrugresistant (PDR) Acinetobacter baumannii and Pseudomonas aeruginosa / J Med. Microbio
/ / Micromedex Healthcare Series Web site
Bergogne-Berezin E / 1996 / Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features / Clin Microbiol Rev 9 : 148 ~ 165
Bonomo RA / 2006 / Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa / Clin Infect Dis 43 (Suppl 2) : 49 ~ 56
Falagas ME / 2006 / The diversity of definitions of multidrug-resistant (MDR) and pandrugresistant (PDR) Acinetobacter baumannii and Pseudomonas aeruginosa / J Med. Microbio
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