지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Purpose: The purpose of the present study was to investigate the pharmacokinetics of urea, a new potential diagnosis reagent of Helicobacter pylori infection. Methods: Considering the mechanism of urea breath test, we determined the excretion of urea in expired air after its oral administration in rats and beagle dogs at the dose of 2 mg/kg (including 50 mCi/mmol 14C-urea 50 μCi/kg for rats and 13.5 μCi/kg for dogs). Results: Urea was rapidly disappeared from the blood circulation by 1 hr after its i.v. bolus injection, followed by a slow disappearance by 24 hr. The half-lives at the distributive phase (t1/2α) and post-distributive phase (t1/2β) were 2 min and 6 hr, respectively. The bioavailability of urea was 64.3% after its oral administration. The values of the volume of distribution (Vdss) and the total body clearance (CLt) after the oral administration were compatible with those after i.v. administration. The recovery of urea in the bile was about 0.1% of the dose by 24 hr after its oral administration. Urea was extensively eliminated in the urine by 48hr. The recovery ratios of urea in the urine and expired air were about 86.8% and 2.99% of the dose by 48 hr, respectively.
Moreover, urea was mostly distributed from the blood circulation to the kidney, followed by being eliminated in the urine without metabolism. The concentration of urea in the kidney was 4.0 times higher than that of plasma at 40min after its oral administration. Conclusions: These findings indicated that oral route appears to be available for the administration of urea. Orally administered urea, thus, was considered to be useful for the diagnosis of Helicobacter pylori infection
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참고문헌 (15)
참고문헌 신청
Westblom TU / 1999 / Dignosis of Helicobacter pylori infection / Cur Topics in Microbiol &Immunol 241:215~235
Kopanski Z / 1996 / Role of enterotest in the diagnosis of the Helicobacter pylori infections / Eur J Med Res 1(11):520~522
Wilcox MH / 1996 / Accuracy of serology for the diagnosis of Helicobacter pylori infection / J Clin Pathol 49:373~376
Cohen H / 1999 / Accuracy of four commercially available serologic tests, including two office-based tests, for diagnosis of Helicobacter pylori / Helicobacter 4:49~53
Puspok A / 1999 / A new, non-invasive method for detection of Helicobacter pylori: validity in the routine clinical setting / Eur J Gastroenterol ＆ Hepatol 11:1139~1142
Kopanski Z / 1996 / Role of enterotest in the diagnosis of the Helicobacter pylori infections / Eur J Med Res 1(11):520~522
Wilcox MH / 1996 / Accuracy of serology for the diagnosis of Helicobacter pylori infection / J Clin Pathol 49:373~376
Cohen H / 1999 / Accuracy of four commercially available serologic tests, including two office-based tests, for diagnosis of Helicobacter pylori / Helicobacter 4:49~53
Puspok A / 1999 / A new, non-invasive method for detection of Helicobacter pylori: validity in the routine clinical setting / Eur J Gastroenterol ＆ Hepatol 11:1139~1142
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