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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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The stability of cefditoren in three kinds of oral liquid preparations at 4 and 25oC was studied for 90 days. Two tablets of 100 mg cefditoren pivoxil were mixed with 200 mL of each oral liquid syrup, which is Pebron® syrup (oxolamine citrate10 mg/mL), Mucopect® syrup (ambroxol hydrochloride 3 mg/mL) or Tyrenol® suspension (acetaminophen encapsulated 32 mg/mL). Three samples of each formulation were refrigerated (4oC) and three were stored at room temperature (25oC). At predetermined time, samples were assayed by stability-indicating HPLC method. The chromatographic
analysis after deliberate degradation showed no evidence of any breakdown product likely to interfere with the chromatographic peak of the parent substance. The relation between cefditoren pivoxil concentration and peak area was linear from 10 to 150 μg/mL (r2=0.9998). The analysis method was precise, with coefficients of variation no greater than 3.6%. Cefditoren was stable in Mucopect® syrup up to 4 weeks regardless of the temperature; in Tyrenol® suspension and Pebron® syrup, it was stable for at least 28 and 45 days, and 7 and 45 days at 25 and 4oC, respectively. The percentages
of initial cefditoren concentration remaining after 90 days were 51.5 ± 1.8 and 80.9 ± 5.6%, 61.7 ± 7.8 and 70.2 ± 7.3%, and 39.9 ± 3.2 and 81.4 ± 5.5% in Mucopect® syrup, Tyrenol® suspension and Pebron® syrup at 25 and
4oC, respectively. The pH variations of all test solutions were minimal, which was within 0.5. The results indicated that the stability of cefditoren was significantly affected by liquid solutions mixed with cefditoren, and storage tempertature.
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